{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun E"],"funding":["National Institutes of Health National Cancer Institute","National Center for Research Resources","U.S. Department of Health and Human Services","National Institute of Diabetes and Digestive and Kidney Diseases","Georgia Clinical and Translational Science Alliance","Vanderbilt Institute for Clinical and Translational Research","National Institutes of Health","Vanderbilt Cancer Center"],"pagination":["1185-1194"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12799435"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(5)"],"pubmed_abstract":["<h4>Background</h4>Carnobacterium maltaromaticum and Faecalibacterium prausnitzii induce de novo gut synthesis of vitamin D to inhibit colorectal carcinogenesis in mice. Magnesium (Mg) treatment increases circulating vitamin D, and Mg homeostasis is dependent on TRPM7 genotype.<h4>Objectives</h4>We hypothesize that Mg treatment increases gut C. maltaromaticum and F. prausnitzii, and the effect differs by TRPM7 polymorphism.<h4>Methods</h4>The Personalized Prevention of Colorectal Cancer Trial is a double-blind, precision-based randomized controlled trial with 240 participants randomly assigned to both treatment and TRPM7 genotype. Stool, rectal swabs, and rectal mucosa were collected.<h4>Results</h4>Of 239 participants who completed the trial, 226 with valid microbiome data were analyzed ("],"journal":["The American journal of clinical nutrition"],"pubmed_title":["Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial."],"pmcid":["PMC12799435"],"funding_grant_id":["UL1 RR024975","UL1TR000445","P30CA68485","VR12960"],"pubmed_authors":["Murff HJ","Azcarate-Peril MA","Yu C","Dai Q","Sun S","Fan L","Shrubsole MJ","Sun E","Zhu X","Ness RM"],"additional_accession":[]},"is_claimable":false,"name":"Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.","description":"<h4>Background</h4>Carnobacterium maltaromaticum and Faecalibacterium prausnitzii induce de novo gut synthesis of vitamin D to inhibit colorectal carcinogenesis in mice. Magnesium (Mg) treatment increases circulating vitamin D, and Mg homeostasis is dependent on TRPM7 genotype.<h4>Objectives</h4>We hypothesize that Mg treatment increases gut C. maltaromaticum and F. prausnitzii, and the effect differs by TRPM7 polymorphism.<h4>Methods</h4>The Personalized Prevention of Colorectal Cancer Trial is a double-blind, precision-based randomized controlled trial with 240 participants randomly assigned to both treatment and TRPM7 genotype. Stool, rectal swabs, and rectal mucosa were collected.<h4>Results</h4>Of 239 participants who completed the trial, 226 with valid microbiome data were analyzed (","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T22:25:26.365Z","creation":"2026-06-06T03:07:42.174Z"},"accession":"S-EPMC12799435","cross_references":{"pubmed":["40946805"],"doi":["10.1016/j.ajcnut.2025.09.011"]}}