{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["76(1)"],"submitter":["Su Q"],"pubmed_abstract":["<h4>Background</h4>The inflammation and cellular dysfunction in periodontitis largely depend on N6-methyladenosine (m<sup>6</sup>A) modification-related epigenetics. However, the role of methyltransferase-like 3 (METTL3)-differentiated m<sup>6</sup>A modification of desmocollin 1 (DSC1) in periodontitis remains to be investigated.<h4>Methods</h4>Periodontal ligament (PDL) tissues were collected from patients with periodontitis and healthy volunteers, and a periodontitis model was constructed using lipopolysaccharide (LPS) and human periodontal ligament fibroblasts (HPLF). METTL3 and DSC1 levels in the specimens and cells were measured using quantitative reverse-transcription polymerase chain reaction. Proliferation, apoptosis, and inflammatory changes were analyzed using CCK-8, EdU, flow c"],"journal":["International dental journal"],"pagination":["109347"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12800397"],"repository":["biostudies-literature"],"pubmed_title":["METTL3-Mediated m6A Modification of DSC1 Alleviates Inflammation and Cellular Dysfunction in Periodontitis."],"pmcid":["PMC12800397"],"pubmed_authors":["Su Q","Chen J"],"additional_accession":[]},"is_claimable":false,"name":"METTL3-Mediated m6A Modification of DSC1 Alleviates Inflammation and Cellular Dysfunction in Periodontitis.","description":"<h4>Background</h4>The inflammation and cellular dysfunction in periodontitis largely depend on N6-methyladenosine (m<sup>6</sup>A) modification-related epigenetics. However, the role of methyltransferase-like 3 (METTL3)-differentiated m<sup>6</sup>A modification of desmocollin 1 (DSC1) in periodontitis remains to be investigated.<h4>Methods</h4>Periodontal ligament (PDL) tissues were collected from patients with periodontitis and healthy volunteers, and a periodontitis model was constructed using lipopolysaccharide (LPS) and human periodontal ligament fibroblasts (HPLF). METTL3 and DSC1 levels in the specimens and cells were measured using quantitative reverse-transcription polymerase chain reaction. Proliferation, apoptosis, and inflammatory changes were analyzed using CCK-8, EdU, flow c","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-06T14:56:16.007Z","creation":"2026-06-01T03:08:10.052Z"},"accession":"S-EPMC12800397","cross_references":{"pubmed":["41453286"],"doi":["10.1016/j.identj.2025.109347"]}}