biostudies-literatureUnknown40(1)Kwon YIC<h4>Background</h4>Unplanned reintubation after combined heart-lung transplantation (HLT) significantly affects morbidity and mortality, yet national data are limited. We evaluated the incidence, predictors, timing, and outcomes associated with reintubation after HLT.<h4>Methods</h4>We retrospectively reviewed adults undergoing primary HLT in the UNOS registry from January 2004 to September 2024. Patients were stratified by reintubation status (defined as re-established mechanical ventilation (MV) after initial extubation). Propensity matching (1:1) balanced recipient and donor characteristics. Multivariable logistic regression models identified independent risk factors.<h4>Results</h4>Among 609 adult HLT recipients, 165 (27.1%) required postoperative reintubation. After 1:1 propensity scoClinical transplantatione70437https://www.ebi.ac.uk/biostudies/studies/S-EPMC12801093biostudies-literatureRisk Factors and Outcomes of Reintubation Following Combined Heart-Lung Transplantation.PMC12801093Ambrosio MFitch ZAl-Yafi MPei JLai AKeller MChery JKasirajan VNicolato PKwon YICHashmi ZABao BPatel JfalseRisk Factors and Outcomes of Reintubation Following Combined Heart-Lung Transplantation.<h4>Background</h4>Unplanned reintubation after combined heart-lung transplantation (HLT) significantly affects morbidity and mortality, yet national data are limited. We evaluated the incidence, predictors, timing, and outcomes associated with reintubation after HLT.<h4>Methods</h4>We retrospectively reviewed adults undergoing primary HLT in the UNOS registry from January 2004 to September 2024. Patients were stratified by reintubation status (defined as re-established mechanical ventilation (MV) after initial extubation). Propensity matching (1:1) balanced recipient and donor characteristics. Multivariable logistic regression models identified independent risk factors.<h4>Results</h4>Among 609 adult HLT recipients, 165 (27.1%) required postoperative reintubation. After 1:1 propensity sco2026-01-01T00:00:00Z2026 Jan2026-06-11T05:00:27.997Z2026-06-11T03:08:00.905ZS-EPMC128010934153230310.1111/ctr.70437