{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zou H"],"funding":["Special funds for clinical research from Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital"],"pagination":["79"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12801749"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(1)"],"pubmed_abstract":["Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease with poor survival, which is characterized by abnormal accumulation of fibrotic tissue in the lung parenchyma. Transforming growth factor-β1 (TGF-β) is a central profibrotic mediator, but the related mechanism of the activation of latent TGF-β has not been conclusively elucidated. A comprehensive study of mRNAs in human IPF was conducted using GSE10667 microarray data from GEO database, and the expression of cartilage intermediate layer protein (CILP) was upregulated among end-stage pulmonary fibrosis (EPF) and acute pulmonary fibrosis (APF) as compared to non-fibrosis tissues. Furthermore, CILP has protein-protein interactions with TGF-β1 through PPI analysis. Therefore, we investigated the potential effects and mechanis"],"journal":["European journal of medical research"],"pubmed_title":["CILP attenuates pulmonary fibrosis through the TGF-β1/SMAD3 pathway."],"pmcid":["PMC12801749"],"funding_grant_id":["QYRYCRC2023005"],"pubmed_authors":["Zou H","Li X","Fei C","Zhao R","Dong J","Li P","Liu C","Liu F","Cheng J"],"additional_accession":[]},"is_claimable":false,"name":"CILP attenuates pulmonary fibrosis through the TGF-β1/SMAD3 pathway.","description":"Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease with poor survival, which is characterized by abnormal accumulation of fibrotic tissue in the lung parenchyma. Transforming growth factor-β1 (TGF-β) is a central profibrotic mediator, but the related mechanism of the activation of latent TGF-β has not been conclusively elucidated. A comprehensive study of mRNAs in human IPF was conducted using GSE10667 microarray data from GEO database, and the expression of cartilage intermediate layer protein (CILP) was upregulated among end-stage pulmonary fibrosis (EPF) and acute pulmonary fibrosis (APF) as compared to non-fibrosis tissues. Furthermore, CILP has protein-protein interactions with TGF-β1 through PPI analysis. Therefore, we investigated the potential effects and mechanis","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-10T05:04:16.986Z","creation":"2026-06-10T03:07:11.033Z"},"accession":"S-EPMC12801749","cross_references":{"pubmed":["41382307"],"doi":["10.1186/s40001-025-03644-7"]}}