biostudies-literatureUnknown26(1)Khurmatullina AR<h4>Background</h4>Gastroesophageal reflux disease (GERD), manifested by heartburn and regurgitation, is a common pregnancy complaint that significantly impairs quality of life. Reported prevalence varies widely, with differences observed across pregnancy trimesters. This first systematic review and meta-analysis synthesizing global data aimed to estimate the pooled prevalence and risk of GERD symptoms during pregnancy, including trimester-specific trends.<h4>Methodology</h4>Following PRISMA 2020 guidelines, a comprehensive literature search was conducted across MEDLINE/PubMed, EMBASE, Cochrane Library, and Google Scholar from 1 January 1975 to 10 July 2025. The protocol was registered in PROSPERO (CRD420251102794). Eligible studies included observational studies reporting the prevalence oBMC pregnancy and childbirth44https://www.ebi.ac.uk/biostudies/studies/S-EPMC12801965biostudies-literatureGlobal prevalence and risk of gastroesophageal reflux disease symptoms in pregnancy: a systematic review and meta-analysis.PMC12801965Sokolov FSKhurmatullina ARMaev IVBeliy PALyamina SVAndreev DNKucheryavyy YAfalseGlobal prevalence and risk of gastroesophageal reflux disease symptoms in pregnancy: a systematic review and meta-analysis.<h4>Background</h4>Gastroesophageal reflux disease (GERD), manifested by heartburn and regurgitation, is a common pregnancy complaint that significantly impairs quality of life. Reported prevalence varies widely, with differences observed across pregnancy trimesters. This first systematic review and meta-analysis synthesizing global data aimed to estimate the pooled prevalence and risk of GERD symptoms during pregnancy, including trimester-specific trends.<h4>Methodology</h4>Following PRISMA 2020 guidelines, a comprehensive literature search was conducted across MEDLINE/PubMed, EMBASE, Cochrane Library, and Google Scholar from 1 January 1975 to 10 July 2025. The protocol was registered in PROSPERO (CRD420251102794). Eligible studies included observational studies reporting the prevalence o2025-01-01T00:00:00Z2025 Dec2026-06-10T05:03:27.046Z2026-06-10T03:07:43.25ZS-EPMC128019654136675110.1186/s12884-025-08569-x