{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nolt GL"],"funding":["NIA NIH HHS","NINDS NIH HHS","NIH HHS","NIGMS NIH HHS"],"pagination":["18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12802005"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Demyelination occurs with aging and is exacerbated in neurodegenerative diseases. During demyelination, microglia upregulate expression of APOE, the gene encoding for the brain's primary lipid transport protein apolipoprotein E (ApoE), which also mediates microglial engulfment and elimination of myelin debris. Compared to the E3 allele of APOE, the E2 allele decreases risk for Alzheimer's disease (AD), while the E4 allele increases AD risk and is associated with an increased severity and progression of multiple sclerosis. Previous work shows that mice expressing E2 exhibit improved microglial function and remyelination compared to mice expressing E4. However, whether microglial-derived APOE is responsible for driving these differences following demyelination, and if microglia-selective exp"],"journal":["Journal of neuroinflammation"],"pubmed_title":["Microglia-derived APOE2 improves remyelination even in the presence of endogenous APOE4."],"pmcid":["PMC12802005"],"funding_grant_id":["T32 AG078110","P20 GM148326","R01AG081421","RF1NS118558","R01 AG081421","RF1 NS118558"],"pubmed_authors":["Lucido CC","Pallerla AV","Brock CR","Nolt GL","Funnell JL","Stephens IO","MacLean SM","Thorpe SP","Morganti JM","Hernandez G","Williams HC","Johnson LA","Golden LR","Adreon DR"],"additional_accession":[]},"is_claimable":false,"name":"Microglia-derived APOE2 improves remyelination even in the presence of endogenous APOE4.","description":"Demyelination occurs with aging and is exacerbated in neurodegenerative diseases. During demyelination, microglia upregulate expression of APOE, the gene encoding for the brain's primary lipid transport protein apolipoprotein E (ApoE), which also mediates microglial engulfment and elimination of myelin debris. Compared to the E3 allele of APOE, the E2 allele decreases risk for Alzheimer's disease (AD), while the E4 allele increases AD risk and is associated with an increased severity and progression of multiple sclerosis. Previous work shows that mice expressing E2 exhibit improved microglial function and remyelination compared to mice expressing E4. However, whether microglial-derived APOE is responsible for driving these differences following demyelination, and if microglia-selective exp","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-11T03:10:01.521Z","creation":"2026-06-11T03:07:50.778Z"},"accession":"S-EPMC12802005","cross_references":{"pubmed":["41382275"],"doi":["10.1186/s12974-025-03639-5"]}}