{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang D"],"funding":["Earmarked Fund for China Agriculture Research System","Science and Technology Department of Gansu Province","Government of Guangdong Province","China Postdoctoral Science Foundation","Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences","Chinese Academy of Agricultural Sciences","National Key Research and Development Program of China"],"pagination":["e0324225"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12802178"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["African swine fever (ASF), caused by the African swine fever virus (ASFV), is a highly contagious disease that affects pigs, resulting in substantial economic losses in the global pig industry. A comprehensive understanding of viral-host protein interactions can facilitate the discovery of therapies for viral infection. In this study, we employ a 4D label-free quantitative proteomics approach to profile a comprehensive protein dynamics analysis in ASFV-infected pigs, identifying over 6,000 proteins across multiple organs. Our results reveal coordinated interorgan responses characterized by inflammatory activation and interferon signaling in defense against ASFV. The protein-protein interaction network analysis uncovers ASFV-induced functional modules, including the unfolded protein respons"],"journal":["mBio"],"pubmed_title":["Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opted by ASFV to promote replication."],"pmcid":["PMC12802178"],"funding_grant_id":["2023SDZG02","2021YFD1800100, 2021YFD1801300","24JRRA804, 23JRRA561, 23JRRA546, 22ZD6NA001, 23JRRA548, 23JRRA1134, 23JRRA561","CAAS-ASTIP-JBGS-20210101","2023M731465","CARS-35, NCTIP-XD/C03","CSLPDCP-202302, CAAS-ASTIP-2024-LVRI, Y2023QC29"],"pubmed_authors":["Liu H","Zhang D","Zheng H","Zhu Z","Cao W","Mao R","Zhang X","Liu B","Shen C","Wang Y","Zhang S","Yang F"],"additional_accession":[]},"is_claimable":false,"name":"Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opted by ASFV to promote replication.","description":"African swine fever (ASF), caused by the African swine fever virus (ASFV), is a highly contagious disease that affects pigs, resulting in substantial economic losses in the global pig industry. A comprehensive understanding of viral-host protein interactions can facilitate the discovery of therapies for viral infection. In this study, we employ a 4D label-free quantitative proteomics approach to profile a comprehensive protein dynamics analysis in ASFV-infected pigs, identifying over 6,000 proteins across multiple organs. Our results reveal coordinated interorgan responses characterized by inflammatory activation and interferon signaling in defense against ASFV. The protein-protein interaction network analysis uncovers ASFV-induced functional modules, including the unfolded protein respons","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T13:19:38.954Z","creation":"2026-07-05T03:08:35.953Z"},"accession":"S-EPMC12802178","cross_references":{"pubmed":["41347792"],"doi":["10.1128/mbio.03242-25"]}}