{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(1)"],"submitter":["Schwabe J"],"funding":["The Max Planck Society"],"pubmed_abstract":["Exported polysaccharides play crucial functions in bacteria. Polysaccharide biosynthesis in the ubiquitous Wzx/Wzy- and ABC-transporter-dependent pathways starts with the transfer of a sugar-1-phosphate from a nucleotide-sugar donor to undecaprenyl phosphate, a reaction catalyzed by a phosphoglycosyl transferase (PGT). Both reaction substrates are limited and shared among multiple glycoconjugate pathways, raising the question of how bacteria regulate these pathways. In <i>Myxococcus xanthu</i>s, EpsZ, which belongs to the family of large monotopic PGTs (monoPGTs), starts the Wzx/Wzy-dependent exopolysaccharide (EPS) biosynthesis. The Dif chemosensory system regulates EPS biosynthesis by an unknown mechanism via the phosphorylated single-domain response regulator EpsW (EpsW~P). Here, we sho"],"journal":["mBio"],"pagination":["e0298625"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12802240"],"repository":["biostudies-literature"],"pubmed_title":["A single-domain response regulator activates exopolysaccharide biosynthesis by interaction with the initiating phosphoglycosyl transferase."],"pmcid":["PMC12802240"],"pubmed_authors":["Rupp O","Sogaard-Andersen L","Goesmann A","Blumenkamp P","Glatter T","Valvano MA","Monjaras-Feria J","Schwabe J"],"additional_accession":[]},"is_claimable":false,"name":"A single-domain response regulator activates exopolysaccharide biosynthesis by interaction with the initiating phosphoglycosyl transferase.","description":"Exported polysaccharides play crucial functions in bacteria. Polysaccharide biosynthesis in the ubiquitous Wzx/Wzy- and ABC-transporter-dependent pathways starts with the transfer of a sugar-1-phosphate from a nucleotide-sugar donor to undecaprenyl phosphate, a reaction catalyzed by a phosphoglycosyl transferase (PGT). Both reaction substrates are limited and shared among multiple glycoconjugate pathways, raising the question of how bacteria regulate these pathways. In <i>Myxococcus xanthu</i>s, EpsZ, which belongs to the family of large monotopic PGTs (monoPGTs), starts the Wzx/Wzy-dependent exopolysaccharide (EPS) biosynthesis. The Dif chemosensory system regulates EPS biosynthesis by an unknown mechanism via the phosphorylated single-domain response regulator EpsW (EpsW~P). Here, we sho","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-10T05:04:20.189Z","creation":"2026-06-10T03:07:12.048Z"},"accession":"S-EPMC12802240","cross_references":{"pubmed":["41313210"],"doi":["10.1128/mbio.02986-25"]}}