{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luchsinger C"],"funding":["AOU NIH HHS","NIAID NIH HHS"],"pagination":["e0286525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12802250"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["HIV-1 viral core transport to the nucleus, an early infection event, triggers the redistribution of cleavage and polyadenylation specificity factors (CPSF) 5 and CPSF6 to nuclear speckles, forming puncta-like structures. CPSF5 and CPSF6 regulate alternative polyadenylation (APA), which governs approximately 70% of gene expression. APA alters the lengths of mRNA 3'-untranslated regions (3'-UTRs), which contain regulatory signals influencing RNA stability, localization, and function. We investigated whether HIV-1 infection-induced changes in CPSF5 and CPSF6 subcellular localization are accompanied by APA changes. Using two independent methodologies to assess APA in human cell lines and primary CD4+ T cells, we found that HIV-1 infection regulates APA, shaped by the interaction of CPSF6 with "],"journal":["mBio"],"pubmed_title":["HIV-1 infection regulates gene expression by altering alternative polyadenylation correlated with CPSF6 and CPSF5 redistribution."],"pmcid":["PMC12802250"],"funding_grant_id":["AI150455","AI087390","R01 AI150455","R01 AI087390"],"pubmed_authors":["Luchsinger C","Huang K-L","Yalamanchili H","Bertelli C","Wagner EJ","Diaz-Griffero F","Dai AZ","Balakrishnan A","Lorenzo-Redondo R","Cui B"],"additional_accession":[]},"is_claimable":false,"name":"HIV-1 infection regulates gene expression by altering alternative polyadenylation correlated with CPSF6 and CPSF5 redistribution.","description":"HIV-1 viral core transport to the nucleus, an early infection event, triggers the redistribution of cleavage and polyadenylation specificity factors (CPSF) 5 and CPSF6 to nuclear speckles, forming puncta-like structures. CPSF5 and CPSF6 regulate alternative polyadenylation (APA), which governs approximately 70% of gene expression. APA alters the lengths of mRNA 3'-untranslated regions (3'-UTRs), which contain regulatory signals influencing RNA stability, localization, and function. We investigated whether HIV-1 infection-induced changes in CPSF5 and CPSF6 subcellular localization are accompanied by APA changes. Using two independent methodologies to assess APA in human cell lines and primary CD4+ T cells, we found that HIV-1 infection regulates APA, shaped by the interaction of CPSF6 with ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T14:58:10.126Z","creation":"2026-06-01T03:08:04.868Z"},"accession":"S-EPMC12802250","cross_references":{"pubmed":["41405390"],"doi":["10.1128/mbio.02865-25"]}}