{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McLean TC"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["e0299125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12802291"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<i>Streptomyces</i> specialized metabolites account for over half of all clinically used antibiotics, as well as numerous antifungal, anticancer, and immunosuppressant agents. Two-component systems, which are widespread in bacteria, are key regulators of antibiotic production in <i>Streptomyces</i> species, yet their activating signals remain poorly understood. CutRS was the first two-component system identified in the genus <i>Streptomyces,</i> and deletion of <i>cutRS</i> in <i>Streptomyces coelicolor</i> was shown to enhance antibiotic production, although its CutR regulon does not include biosynthetic genes. Here, we used <i>Streptomyces venezuelae</i> NRRL B-65442 to further investigate CutRS function. We show that deletion of <i>cutRS</i> increases growth rate and a reversal of the g"],"journal":["mBio"],"pubmed_title":["The conserved two-component systems CutRS and CssRS control the protein secretion stress response in &lt;i&gt;Streptomyces&lt;/i&gt;."],"pmcid":["PMC12802291"],"funding_grant_id":["BB/X01097X/1","BB/M011216/1","BBS/E/J/000PR9790"],"pubmed_authors":["Martins C","Batey SFD","Chandra G","Beaton ADM","McLean TC","Saalbach G","China J","Hutchings MI","Holmes NA","Wilkinson B"],"additional_accession":[]},"is_claimable":false,"name":"The conserved two-component systems CutRS and CssRS control the protein secretion stress response in &lt;i&gt;Streptomyces&lt;/i&gt;.","description":"<i>Streptomyces</i> specialized metabolites account for over half of all clinically used antibiotics, as well as numerous antifungal, anticancer, and immunosuppressant agents. Two-component systems, which are widespread in bacteria, are key regulators of antibiotic production in <i>Streptomyces</i> species, yet their activating signals remain poorly understood. CutRS was the first two-component system identified in the genus <i>Streptomyces,</i> and deletion of <i>cutRS</i> in <i>Streptomyces coelicolor</i> was shown to enhance antibiotic production, although its CutR regulon does not include biosynthetic genes. Here, we used <i>Streptomyces venezuelae</i> NRRL B-65442 to further investigate CutRS function. We show that deletion of <i>cutRS</i> increases growth rate and a reversal of the g","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-11T04:57:35.947Z","creation":"2026-06-11T03:08:14.6Z"},"accession":"S-EPMC12802291","cross_references":{"pubmed":["41395939"],"doi":["10.1128/mbio.02991-25"]}}