{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iyilikci O"],"funding":["NIMH NIH HHS"],"pagination":["4522-4536.e6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12802583"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(18)"],"pubmed_abstract":["Social isolation enhances sociability, suggesting that social behavior is maintained through a homeostatic mechanism. Further, mammalian social needs shift dramatically from infancy through adolescence into adulthood, raising the question of whether the neural mechanisms governing this homeostatic regulation evolve across developmental stages. Here, we show that agouti-related peptide (Agrp) neurons in the arcuate nucleus of the hypothalamus, which are known to drive hunger in adults, are activated by social isolation from weaning through adolescence but not in adulthood. Importantly, the activity of these neurons is critical for social behavior during adolescence: inhibiting Agrp neurons reduced isolation-induced sociability in juveniles, but not in adults, and Agrp neuron activation prom"],"journal":["Current biology : CB"],"pubmed_title":["Age-specific regulation of sociability by hypothalamic Agrp neurons."],"pmcid":["PMC12802583"],"funding_grant_id":["R01 MH130825","R01 MH125008"],"pubmed_authors":["Li Y","Santana GM","Bober J","Pelts M","Kim L","Zimmer MR","Iyilikci O","Dietrich MO"],"additional_accession":[]},"is_claimable":false,"name":"Age-specific regulation of sociability by hypothalamic Agrp neurons.","description":"Social isolation enhances sociability, suggesting that social behavior is maintained through a homeostatic mechanism. Further, mammalian social needs shift dramatically from infancy through adolescence into adulthood, raising the question of whether the neural mechanisms governing this homeostatic regulation evolve across developmental stages. Here, we show that agouti-related peptide (Agrp) neurons in the arcuate nucleus of the hypothalamus, which are known to drive hunger in adults, are activated by social isolation from weaning through adolescence but not in adulthood. Importantly, the activity of these neurons is critical for social behavior during adolescence: inhibiting Agrp neurons reduced isolation-induced sociability in juveniles, but not in adults, and Agrp neuron activation prom","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-07-15T06:14:16.751Z","creation":"2026-06-30T03:20:42.863Z"},"accession":"S-EPMC12802583","cross_references":{"pubmed":["40907492"],"doi":["10.1016/j.cub.2025.08.014"]}}