{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["NHLBI NIH HHS","NINDS NIH HHS"],"pagination":["eaeb6538"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12802829"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["Ideal orthopedic biomaterials should replicate both the hierarchical structure and exceptional mechanical strength of natural bone. Traditional polymer-hydroxyapatite composites, typically limited up to 40 wt % hydroxyapatite, offer only modest mechanical improvements. Efforts to enhance strength by using stiffer polymers have largely failed, as increased polymer stiffness does not translate to improved composite mechanics. In contrast, natural bone's load-bearing capability arises from the synergy between citrate, soft collagen, and ultrathin hydroxyapatite nanocrystals (~3 nanometers). Here, we show that elastic poly(octamethylene citrate) enables up to 60 wt % hydroxyapatite incorporation, mimicking the bone's mineral content. Through a top-down \"citrification\" process and hot pressing,"],"journal":["Science advances"],"pubmed_title":["The genesis of citrated ultrathin hydroxyapatite nanorods."],"pmcid":["PMC12802829"],"funding_grant_id":["R01 HL158204","R01 NS123433"],"pubmed_authors":["Yang J","Tan X","Jiang H","Gerhard E","Yan S","Wang Y","Xu H"],"additional_accession":[]},"is_claimable":false,"name":"The genesis of citrated ultrathin hydroxyapatite nanorods.","description":"Ideal orthopedic biomaterials should replicate both the hierarchical structure and exceptional mechanical strength of natural bone. Traditional polymer-hydroxyapatite composites, typically limited up to 40 wt % hydroxyapatite, offer only modest mechanical improvements. Efforts to enhance strength by using stiffer polymers have largely failed, as increased polymer stiffness does not translate to improved composite mechanics. In contrast, natural bone's load-bearing capability arises from the synergy between citrate, soft collagen, and ultrathin hydroxyapatite nanocrystals (~3 nanometers). Here, we show that elastic poly(octamethylene citrate) enables up to 60 wt % hydroxyapatite incorporation, mimicking the bone's mineral content. Through a top-down \"citrification\" process and hot pressing,","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-10T05:04:23.368Z","creation":"2026-06-10T03:07:12.511Z"},"accession":"S-EPMC12802829","cross_references":{"pubmed":["41533801"],"doi":["10.1126/sciadv.aeb6538"]}}