{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hodzelmans JJA"],"funding":["Janssen-Cilag","Health Foundation Limburg","Ministerie van Economische Zaken","Sanofi-Aventis Netherlands B.V. (Gouda, The Netherlands)","Provincie Limburg","Stichting De Weijerhorst","Novo Nordisk Pharma","CARIM School for Cardiovascular Diseases, Universiteit Maastricht","Pearl String Initiative Diabetes","NUTRIM School of Nutrition and Translational Research in Metabolism","CAPHRI Care and Public Health Research Institute","Stichting Sint Annadal","the Cardiovascular Center (CVC, Maastricht, The Netherlands)","Janssen Pharmaceuticals","European Regional Development Fund"],"pagination":["283-291"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12803540"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["73(2)"],"pubmed_abstract":["Introduction/aims
To study the association of risk factors with axonal degeneration, based on below-threshold sural nerve amplitudes, as a proxy for distal symmetric polyneuropathy (DSP). In particular, to assess the differential contribution of risk factors in diabetes status subgroups.Methods
In 7242 participants of The Maastricht Study, a population-based cohort (aged 40 to 75 years, southern part of the Netherlands) focusing on type 2 diabetes (T2DM), associations between below-threshold sural nerve amplitudes (< 2.3 μV) and risk factors (diabetes status, demographics, anthropometrics, office systolic blood pressure, lifestyle, medication intake, and lipid profiles) were determined using logistic regression analysis in the total population and after stratification for n"],"journal":["Muscle & nerve"],"pubmed_title":["Risk Factors of Sural Nerve Axonal Degeneration Using Clinically Relevant Thresholds in Context of Glucose Metabolism: The Maastricht Study."],"pmcid":["PMC12803540"],"funding_grant_id":["31O.041"],"pubmed_authors":["Sutedja NA","Reulen JPH","Janssen MLF","Koster A","Mess WH","Hodzelmans JJA","Schaper NC"],"additional_accession":[]},"is_claimable":false,"name":"Risk Factors of Sural Nerve Axonal Degeneration Using Clinically Relevant Thresholds in Context of Glucose Metabolism: The Maastricht Study.","description":"Introduction/aims
To study the association of risk factors with axonal degeneration, based on below-threshold sural nerve amplitudes, as a proxy for distal symmetric polyneuropathy (DSP). In particular, to assess the differential contribution of risk factors in diabetes status subgroups.Methods
In 7242 participants of The Maastricht Study, a population-based cohort (aged 40 to 75 years, southern part of the Netherlands) focusing on type 2 diabetes (T2DM), associations between below-threshold sural nerve amplitudes (< 2.3 μV) and risk factors (diabetes status, demographics, anthropometrics, office systolic blood pressure, lifestyle, medication intake, and lipid profiles) were determined using logistic regression analysis in the total population and after stratification for n","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-11T05:21:02.606Z","creation":"2026-06-11T03:08:07.015Z"},"accession":"S-EPMC12803540","cross_references":{"pubmed":["41342097"],"doi":["10.1002/mus.70088"]}}