biostudies-literatureUnknown27(12)Kunz M<h4>Aims</h4>Non-adherence to guideline-directed medical therapy may worsen outcomes in chronic heart failure (CHF). Objectively assessed adherence in patients presenting with acutely decompensated heart failure (ADHF) remains largely unexplored. This study evaluated adherence to medication in patients with ADHF presenting in the emergency department.<h4>Methods and results</h4>This cross-sectional study assessed medication adherence using both indirect (self-reported) and direct methods (qualitative toxicological analysis in urine). A total of 100 patients were included of whom 61% were men, with a mean age of 77.9 ± 10.1 years, and a median N-terminal pro-B-type natriuretic peptide level of 4846 pg/ml. In 39% of patients, all prescribed CHF medications were detected in urine, indicating European journal of heart failure2763-2772https://www.ebi.ac.uk/biostudies/studies/S-EPMC12803543biostudies-literatureMedication adherence in patients with acutely decompensated heart failure: A cross-sectional study in the emergency department (ADHF-ED).PMC12803543Lauder LGotzinger FMahfoud FKunz MBohm MSchaar JMKindermann IMeyer MRWelker KRSchulz MfalseMedication adherence in patients with acutely decompensated heart failure: A cross-sectional study in the emergency department (ADHF-ED).<h4>Aims</h4>Non-adherence to guideline-directed medical therapy may worsen outcomes in chronic heart failure (CHF). Objectively assessed adherence in patients presenting with acutely decompensated heart failure (ADHF) remains largely unexplored. This study evaluated adherence to medication in patients with ADHF presenting in the emergency department.<h4>Methods and results</h4>This cross-sectional study assessed medication adherence using both indirect (self-reported) and direct methods (qualitative toxicological analysis in urine). A total of 100 patients were included of whom 61% were men, with a mean age of 77.9 ± 10.1 years, and a median N-terminal pro-B-type natriuretic peptide level of 4846 pg/ml. In 39% of patients, all prescribed CHF medications were detected in urine, indicating 2025-01-01T00:00:00Z2025 Dec2026-06-06T14:55:53.122Z2026-06-01T03:08:02.814ZS-EPMC128035434063730610.1002/ejhf.3756