biostudies-literatureMaier ABoris Canessa ALS StiftungMartin Herrenknecht Fonds for ALS Research250-259https://www.ebi.ac.uk/biostudies/studies/S-EPMC12803583biostudies-literatureUnknown73(2)<h4>Introduction/aims</h4>The harmonized version of the ALS Functional Rating Scale - Revised (ALSFRS-R) is typically administered according to standard operating procedures (SOPs) to ensure procedural consistency. In contrast, obtaining the self-explanatory (SE) version of the ALSFRS-R does not include the use of SOPs. The aim of this study was to examine the level of agreement between the harmonized and the SE version of the ALSFRS-R in a cohort of ALS patients.<h4>Methods</h4>In a prospective study, the harmonized ALSFRS-R was assessed in 107 ALS patients. In parallel, all patients independently completed the ALSFRS-R-SE, either on a printed form (n = 36) or remotely via the ALS App (n = 71). Agreement between methods was investigated using Spearman's correlation, Lin's concordance corrMuscle & nerveAgreement Between the Harmonized and the Self-Explanatory Versions of the Revised ALS Functional Rating Scale in a Clinical Setting.PMC12803583H4017703513237604Riitano ASpittel SMeyer TKettemann DKoc YKolzarek FMunch CMaier ANorden JSchmitt PSteinfurth LSubramanian SfalseAgreement Between the Harmonized and the Self-Explanatory Versions of the Revised ALS Functional Rating Scale in a Clinical Setting.<h4>Introduction/aims</h4>The harmonized version of the ALS Functional Rating Scale - Revised (ALSFRS-R) is typically administered according to standard operating procedures (SOPs) to ensure procedural consistency. In contrast, obtaining the self-explanatory (SE) version of the ALSFRS-R does not include the use of SOPs. The aim of this study was to examine the level of agreement between the harmonized and the SE version of the ALSFRS-R in a cohort of ALS patients.<h4>Methods</h4>In a prospective study, the harmonized ALSFRS-R was assessed in 107 ALS patients. In parallel, all patients independently completed the ALSFRS-R-SE, either on a printed form (n = 36) or remotely via the ALS App (n = 71). Agreement between methods was investigated using Spearman's correlation, Lin's concordance corr2026-01-01T00:00:00Z2026 Feb2026-06-06T13:18:09.176Z2026-05-31T03:07:22.079ZS-EPMC128035834132855510.1002/mus.70092