{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(12)"],"submitter":["Del Mestre E"],"pubmed_abstract":["Aims
The prognostic significance of detecting left ventricular (LV) systolic dysfunction during family screening programmes (FSPs) in relatives of probands affected by dilated (DCM) and non-dilated left ventricular (NDLVC) cardiomyopathies remain unclear. This study sought to evaluate the prognostic role of LV systolic dysfunction detection in relatives of DCM/NDLVC probands and to define the most accurate FSP.Methods and results
Baseline and follow-up data of first-degree relatives of probands affected by DCM/NDLVC were collected. The primary outcome was all-cause death and heart transplantation. Secondary heart failure (HF) and arrhythmic outcomes were also included. A total of 492 first degree relatives were enrolled. During a median follow-up of 110 months (interquartil"],"journal":["European journal of heart failure"],"pagination":["3260-3268"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12803633"],"repository":["biostudies-literature"],"pubmed_title":["Prediction and prognostic role of left ventricular systolic dysfunction in family screening for dilated cardiomyopathy and non-dilated left ventricular cardiomyopathy."],"pmcid":["PMC12803633"],"pubmed_authors":["Severini GM","Lenarduzzi S","Girotto G","Folgheraiter A","Gandin I","Gigli M","Spedicati B","Stolfo D","Sinagra G","Dal Ferro M","Rizzi JG","Korcova R","Pio Loco Detto Gava C","Setti M","Mestroni L","Paldino A","Merlo M","Del Mestre E"],"additional_accession":[]},"is_claimable":false,"name":"Prediction and prognostic role of left ventricular systolic dysfunction in family screening for dilated cardiomyopathy and non-dilated left ventricular cardiomyopathy.","description":"Aims
The prognostic significance of detecting left ventricular (LV) systolic dysfunction during family screening programmes (FSPs) in relatives of probands affected by dilated (DCM) and non-dilated left ventricular (NDLVC) cardiomyopathies remain unclear. This study sought to evaluate the prognostic role of LV systolic dysfunction detection in relatives of DCM/NDLVC probands and to define the most accurate FSP.Methods and results
Baseline and follow-up data of first-degree relatives of probands affected by DCM/NDLVC were collected. The primary outcome was all-cause death and heart transplantation. Secondary heart failure (HF) and arrhythmic outcomes were also included. A total of 492 first degree relatives were enrolled. During a median follow-up of 110 months (interquartil","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T15:15:53.576Z","creation":"2026-06-01T03:10:53.494Z"},"accession":"S-EPMC12803633","cross_references":{"pubmed":["40222818"],"doi":["10.1002/ejhf.3657"]}}