biostudies-literatureUnknown27(12)Del Mestre E<h4>Aims</h4>The prognostic significance of detecting left ventricular (LV) systolic dysfunction during family screening programmes (FSPs) in relatives of probands affected by dilated (DCM) and non-dilated left ventricular (NDLVC) cardiomyopathies remain unclear. This study sought to evaluate the prognostic role of LV systolic dysfunction detection in relatives of DCM/NDLVC probands and to define the most accurate FSP.<h4>Methods and results</h4>Baseline and follow-up data of first-degree relatives of probands affected by DCM/NDLVC were collected. The primary outcome was all-cause death and heart transplantation. Secondary heart failure (HF) and arrhythmic outcomes were also included. A total of 492 first degree relatives were enrolled. During a median follow-up of 110 months (interquartilEuropean journal of heart failure3260-3268https://www.ebi.ac.uk/biostudies/studies/S-EPMC12803633biostudies-literaturePrediction and prognostic role of left ventricular systolic dysfunction in family screening for dilated cardiomyopathy and non-dilated left ventricular cardiomyopathy.PMC12803633Severini GMLenarduzzi SGirotto GFolgheraiter AGandin IGigli MSpedicati BStolfo DSinagra GDal Ferro MRizzi JGKorcova RPio Loco Detto Gava CSetti MMestroni LPaldino AMerlo MDel Mestre EfalsePrediction and prognostic role of left ventricular systolic dysfunction in family screening for dilated cardiomyopathy and non-dilated left ventricular cardiomyopathy.<h4>Aims</h4>The prognostic significance of detecting left ventricular (LV) systolic dysfunction during family screening programmes (FSPs) in relatives of probands affected by dilated (DCM) and non-dilated left ventricular (NDLVC) cardiomyopathies remain unclear. This study sought to evaluate the prognostic role of LV systolic dysfunction detection in relatives of DCM/NDLVC probands and to define the most accurate FSP.<h4>Methods and results</h4>Baseline and follow-up data of first-degree relatives of probands affected by DCM/NDLVC were collected. The primary outcome was all-cause death and heart transplantation. Secondary heart failure (HF) and arrhythmic outcomes were also included. A total of 492 first degree relatives were enrolled. During a median follow-up of 110 months (interquartil2025-01-01T00:00:00Z2025 Dec2026-06-06T15:15:53.576Z2026-06-01T03:10:53.494ZS-EPMC128036334022281810.1002/ejhf.3657