biostudies-literatureCampbell RTBritish Heart FoundationRoche DiagnosticsAstraZeneca3401-3410https://www.ebi.ac.uk/biostudies/studies/S-EPMC12803686biostudies-literatureUnknown27(12)<h4>Aims</h4>Echocardiography is a rate-limiting step in the timely diagnosis of heart failure (HF). Automated reporting of echocardiograms has the potential to streamline workflow. The aim of this study was to test the diagnostic accuracy of fully automated artificial intelligence (AI) analysis of images acquired using handheld echocardiography and its interchangeability with expert human-analysed cart-based echocardiograms in a real-world cohort with suspected HF.<h4>Methods and results</h4>In this multicentre, prospective, observational study, patients with suspected HF had two echocardiograms: one handheld portable and one cart-based scan. Both echocardiograms were analysed using fully automated AI software and by human expert sonographers. The primary endpoint was the diagnostic accurEuropean journal of heart failureArtificial intelligence fully automated analysis of handheld echocardiography in real-world patients with suspected heart failure.PMC12803686RE/18/6/34217Nordin SMcKinley GMurphy CLCampbell RTMacklin LMcConnachie ATaylor KTurnbull PTaylor-Sweet DMcIntyre ALam CSPLee MMYBrooksbank KJMOsmanska JMcDowell KSonecki PHainey HMcMurray JJVButler EJarvie JLowe DJCurtain JPPetrie MCMangion KHartshorne-Evans NGraham FJDocherty KFPellicori PSimpson JWelsh PAdamson CMcCoubrey AHaig CfalseArtificial intelligence fully automated analysis of handheld echocardiography in real-world patients with suspected heart failure.<h4>Aims</h4>Echocardiography is a rate-limiting step in the timely diagnosis of heart failure (HF). Automated reporting of echocardiograms has the potential to streamline workflow. The aim of this study was to test the diagnostic accuracy of fully automated artificial intelligence (AI) analysis of images acquired using handheld echocardiography and its interchangeability with expert human-analysed cart-based echocardiograms in a real-world cohort with suspected HF.<h4>Methods and results</h4>In this multicentre, prospective, observational study, patients with suspected HF had two echocardiograms: one handheld portable and one cart-based scan. Both echocardiograms were analysed using fully automated AI software and by human expert sonographers. The primary endpoint was the diagnostic accur2025-01-01T00:00:00Z2025 Dec2026-06-06T14:57:17.137Z2026-06-01T03:07:40.638ZS-EPMC128036864070288010.1002/ejhf.3783