{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(2)"],"submitter":["Begre L"],"pubmed_abstract":["<h4>Background & aims</h4>HBsAg loss improves clinical outcomes in persons with HIV and HBV coinfection. We aimed to evaluate if hepatitis B core-related antigen and circulating HBV RNA levels were associated with HBsAg loss in Euro-B, a multi-cohort collaboration including data from the Swiss HIV Cohort Study, EuroSIDA, and the French HIV/HBV cohort.<h4>Methods</h4>We included persons with HIV, a positive HBsAg, and ≥6 months of follow-up on tenofovir-containing antiretroviral therapy. We evaluated quantitative HBsAg, HBV DNA, hepatitis B core-related antigen, and HBV RNA levels over time and assessed HBsAg loss (<i>i.e.</i> quantitative HBsAg <0.05 IU/ml) during tenofovir therapy.<h4>Results</h4>Among 599 participants median age was 41 years (IQR 35-47), 18.4% were female and 47.3% HBeAg"],"journal":["JHEP reports : innovation in hepatology"],"pagination":["101671"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12803887"],"repository":["biostudies-literature"],"pubmed_title":["Circulating HBV RNA and hepatitis B core-related antigen as determinants of HBsAg loss in persons with HIV in Europe."],"pmcid":["PMC12803887"],"pubmed_authors":["Anagnostopoulos A","Paredes R","Knappik M","Boffito M","Mackintosh C","Huber M","Larsen JF","Jablonowska E","Nesterova O","Nicca D","Timiryasova A","Lundgren J","Gardizi M","Degen O","Hosli I","Shahi S","Hetman L","Ostergaard L","Kumar LR","Zoulim F","Trofimova T","Gracia MG","Reikvam DH","Machala L","Lacombe K","Chivite I","Bernasconi E","Beguelin C","Elbirt D","Roper F","Devitt E","Puig J","Bogner J","Furrer H","Girard PM","Marzolini C","Stockle M","Mansinho K","Suter-Riniker F","Kamerys J","Ambrosioni J","Cozzi-Lepri A","F SR","Mitsura VM","Labhardt ND","Aksak-Was B","Carlander C","Kowalska JD","Sedlacek D","Foncillas A","De Scheerder M","Fux CA","Batutu R","Plissonnier ML","Kundro M","Klimkait T","Swiss HIV Cohort Study, EuroSIDA and French HIV/HBV and Biliver cohorts","Johansen IS","Muller N","Winston A","Blanco JL","Stefan C","Battegay M","Levrero M","Szetela B","Delforge M","Trkola A","Calmy A","Peters L","Gonzalez-Cordon A","Yerly S","Braun D","Braun DL","Kuznetsova A","Aebi-Popp K","Wattad LM","Boyd A","Rougier H","Inglot M","Guaraldi G","Duvivier C","De A Arroniz ES","Trajanovska J","Benfield T","Zilmer K","Weisser M","Martinez E","Keiser O","Lascoux-Combe C","Paissios N","Mansson F","Parczewski M","Rasmussen LD","Rockstroh J","Berrocal L","Viard JP","Pantaleo G","Brannstrom J","Adamis G","Wandeler G","Tarr PE","Beniowski M","Mora L","Inciarte A","Losso M","Aho I","Burns F","Miranda C","Nemeth J","Rozplochowski B","Valk MV","Cichon P","Wiese L","Maltez F","Dollenmaier G","Ranin J","Elzi L","Hoffmann C","Laguno M","De Wit S","Abela IA","Knysz B","Lehmann C","Domingo P","Kryshchuk A","Delaugerre C","de Lazzaari E","Edwards S","Members of the French HIV/HBV and Biliver cohorts","Schiavo F","Topalovic J","Miro JM","Pepa B","Schmid P","Jackson-Perry D","Neesgaard B","Hoffmann M","Abutidze A","Kuzovatova E","Gusev D","Segeral O","Elsing TW","Szlavik J","Egger M","Fellay J","Nozza S","Perreau M","Pradier C","Mozer-Lisewska I","Castagna A","Vdoushkina E","Kirk O","Torres B","Ponz A","Nielsen LN","Scholtes C","Santos JR","Testoni B","Harxhi A","Sarcletti M","Members of the EuroSIDA Study Group","Fontas E","Oprea C","Salazar-Vizcaya LP","Elinav H","Callau P","Kouyos RD","Uzdaviniene V","Zagalo A","Tau L","Orkin C","Clarke A","Martinez de Tejada B","Gunthard HF","Mularska E","Metzner KJ","Hachfeld A","Begre L","Fehr JS","Borodulina E","Wojcik K","Karpov I","Kahlert CR","Frankenhuijsen M","Jilich D","Tomazic J","Miailhes P","Begovac J","Staub T","Paduto D","Matulionyte R","Rauch A","Bondarenko OA","Sonnerborg A","Heil M","Paioni P","Hirsch HH","Falconer K","Rockstroh JK","Gerstoft J","Hasse B","Mallolas J","Gozlan J","Notter J","Marchetti G","Leuzinger K","Martinez-Rebollar M","Sambatakou H","Fischer AH","Cavassini M","Kusejko K","Raben D","Penzing K","Chas J","Bannister W","Jaschinski N","Bucher HC","Clumeck N","Gottfredsson M","Alcami J","Ciuffi A","Boesecke C","Lebech AM","Ridolfo A","Mar GM","Mussini C","Radoi R","Bakowska E","Kovari H","Hans-Ulrich Haerry D"],"additional_accession":[]},"is_claimable":false,"name":"Circulating HBV RNA and hepatitis B core-related antigen as determinants of HBsAg loss in persons with HIV in Europe.","description":"<h4>Background & aims</h4>HBsAg loss improves clinical outcomes in persons with HIV and HBV coinfection. We aimed to evaluate if hepatitis B core-related antigen and circulating HBV RNA levels were associated with HBsAg loss in Euro-B, a multi-cohort collaboration including data from the Swiss HIV Cohort Study, EuroSIDA, and the French HIV/HBV cohort.<h4>Methods</h4>We included persons with HIV, a positive HBsAg, and ≥6 months of follow-up on tenofovir-containing antiretroviral therapy. We evaluated quantitative HBsAg, HBV DNA, hepatitis B core-related antigen, and HBV RNA levels over time and assessed HBsAg loss (<i>i.e.</i> quantitative HBsAg <0.05 IU/ml) during tenofovir therapy.<h4>Results</h4>Among 599 participants median age was 41 years (IQR 35-47), 18.4% were female and 47.3% HBeAg","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-13T04:49:43.147Z","creation":"2026-06-13T03:09:17.749Z"},"accession":"S-EPMC12803887","cross_references":{"pubmed":["41551412"],"doi":["10.1016/j.jhepr.2025.101671"]}}