{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["91"],"submitter":["Ciancia S"],"pubmed_abstract":["<h4>Background</h4>The number of transgender and gender-diverse (TGD) minors seeking medical care continues to increase, however data on long-term effects of gender-affirming hormone therapy (GAHT) started in adolescence remain limited.<h4>Methods</h4>This single center study (Ghent University Hospital, Belgium) included a cohort of TGD individuals registered female at birth (RFAB, n = 91) and registered male at birth (RMAB, n = 26) who commenced GAHT during adolescence and were followed into adulthood for up to 10 years. Participants were enrolled retrospectively between September 2023 and December 2024. Outcomes assessed cross-sectionally included areal bone mineral density (aBMD), body composition, handgrip strength, and overall life satisfaction. Lifestyle factors such as alcohol and t"],"journal":["EClinicalMedicine"],"pagination":["103724"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12803899"],"repository":["biostudies-literature"],"pubmed_title":["Effects of gender-affirming hormone therapy from adolescence to adulthood on bone mineral density, body composition and muscle strength."],"pmcid":["PMC12803899"],"pubmed_authors":["Klink D","Ciancia S","T'Sjoen G","Vervalcke J","Cools M"],"additional_accession":[]},"is_claimable":false,"name":"Effects of gender-affirming hormone therapy from adolescence to adulthood on bone mineral density, body composition and muscle strength.","description":"<h4>Background</h4>The number of transgender and gender-diverse (TGD) minors seeking medical care continues to increase, however data on long-term effects of gender-affirming hormone therapy (GAHT) started in adolescence remain limited.<h4>Methods</h4>This single center study (Ghent University Hospital, Belgium) included a cohort of TGD individuals registered female at birth (RFAB, n = 91) and registered male at birth (RMAB, n = 26) who commenced GAHT during adolescence and were followed into adulthood for up to 10 years. Participants were enrolled retrospectively between September 2023 and December 2024. Outcomes assessed cross-sectionally included areal bone mineral density (aBMD), body composition, handgrip strength, and overall life satisfaction. Lifestyle factors such as alcohol and t","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T17:14:48.004Z","creation":"2026-06-03T03:09:56.844Z"},"accession":"S-EPMC12803899","cross_references":{"pubmed":["41552001"],"doi":["10.1016/j.eclinm.2025.103724"]}}