biostudies-literatureUnknown91Ciancia S<h4>Background</h4>The number of transgender and gender-diverse (TGD) minors seeking medical care continues to increase, however data on long-term effects of gender-affirming hormone therapy (GAHT) started in adolescence remain limited.<h4>Methods</h4>This single center study (Ghent University Hospital, Belgium) included a cohort of TGD individuals registered female at birth (RFAB, n = 91) and registered male at birth (RMAB, n = 26) who commenced GAHT during adolescence and were followed into adulthood for up to 10 years. Participants were enrolled retrospectively between September 2023 and December 2024. Outcomes assessed cross-sectionally included areal bone mineral density (aBMD), body composition, handgrip strength, and overall life satisfaction. Lifestyle factors such as alcohol and tEClinicalMedicine103724https://www.ebi.ac.uk/biostudies/studies/S-EPMC12803899biostudies-literatureEffects of gender-affirming hormone therapy from adolescence to adulthood on bone mineral density, body composition and muscle strength.PMC12803899Klink DCiancia ST'Sjoen GVervalcke JCools MfalseEffects of gender-affirming hormone therapy from adolescence to adulthood on bone mineral density, body composition and muscle strength.<h4>Background</h4>The number of transgender and gender-diverse (TGD) minors seeking medical care continues to increase, however data on long-term effects of gender-affirming hormone therapy (GAHT) started in adolescence remain limited.<h4>Methods</h4>This single center study (Ghent University Hospital, Belgium) included a cohort of TGD individuals registered female at birth (RFAB, n = 91) and registered male at birth (RMAB, n = 26) who commenced GAHT during adolescence and were followed into adulthood for up to 10 years. Participants were enrolled retrospectively between September 2023 and December 2024. Outcomes assessed cross-sectionally included areal bone mineral density (aBMD), body composition, handgrip strength, and overall life satisfaction. Lifestyle factors such as alcohol and t2026-01-01T00:00:00Z2026 Jan2026-06-06T17:14:48.004Z2026-06-03T03:09:56.844ZS-EPMC128038994155200110.1016/j.eclinm.2025.103724