biostudies-literatureUnknown10(1)Weisinger J<h4>Background</h4>Despite improvement in acute care of immune-mediated thrombotic thrombocytopenic purpura (iTTP), numerous studies showed that patients with iTTP have inferior mental health and health-related quality of life (HRQoL). Caplacizumab led to shorter hospitalization, less plasma exchange, and improved survival in iTTP and might influence long-term HRQoL.<h4>Objectives</h4>We aimed to address the impact of iTTP on HRQoL, posttraumatic stress disease, depression, and anxiety, as well as the possible role of caplacizumab on improving these features.<h4>Methods</h4>We conducted a survey among patients with iTTP enrolled in the French thrombotic microangiopathy registry: patients completed the Short Form (SF)-36 HRQoL, the Hospital Anxiety and Depression Scale screening for anxietyResearch and practice in thrombosis and haemostasis103297https://www.ebi.ac.uk/biostudies/studies/S-EPMC12804100biostudies-literatureHealth-related quality of life and mental health in autoimmune thrombotic thrombocytopenic purpura patients in the caplacizumab era.PMC12804100Azoulay EAugusto JFChoukroun GJoly BJaccard AMoranne OPoullin PWeisinger JVeyradier APapo TPresne CBouzid RFadlallah JCartery CLievre LCoppo PTites CBenhamou YBaba AGilardin LfalseHealth-related quality of life and mental health in autoimmune thrombotic thrombocytopenic purpura patients in the caplacizumab era.<h4>Background</h4>Despite improvement in acute care of immune-mediated thrombotic thrombocytopenic purpura (iTTP), numerous studies showed that patients with iTTP have inferior mental health and health-related quality of life (HRQoL). Caplacizumab led to shorter hospitalization, less plasma exchange, and improved survival in iTTP and might influence long-term HRQoL.<h4>Objectives</h4>We aimed to address the impact of iTTP on HRQoL, posttraumatic stress disease, depression, and anxiety, as well as the possible role of caplacizumab on improving these features.<h4>Methods</h4>We conducted a survey among patients with iTTP enrolled in the French thrombotic microangiopathy registry: patients completed the Short Form (SF)-36 HRQoL, the Hospital Anxiety and Depression Scale screening for anxiety2026-01-01T00:00:00Z2026 Jan2026-06-10T05:15:11.792Z2026-06-10T03:07:29.693ZS-EPMC128041004155274710.1016/j.rpth.2025.103297