{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["57"],"submitter":["Roncali L"],"pubmed_abstract":["Background and purpose
Oral squamous cell carcinoma (OSCC) remains a major clinical challenge, with limited therapeutic options and poor outcomes. Among the emerging approaches to address this unmet need, spatially fractionated radiotherapy (SFRT) using mini-GRID patterns has emerged as a promising approach, delivering high radiation doses through narrowly collimated beamlets that spare intervening normal tissue and may enhance the therapeutic index. This study evaluated the efficacy and safety of mini-GRID RT in an orthotopic, syngeneic murine model of OSCC.Materials and methods
C57BL/6 mice bearing MOC1 tumors were randomized to receive conventional radiotherapy (conv-RT; 20 Gy), mini-GRID RT (20 Gy average dose), or no treatment. Endpoints included survival, tumor growth"],"journal":["Clinical and translational radiation oncology"],"pagination":["101101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12804384"],"repository":["biostudies-literature"],"pubmed_title":["Mini-GRID enhances survival and reduces toxicity in an orthotopic murine model of oral squamous cell carcinoma: A proof-of-concept study."],"pmcid":["PMC12804384"],"pubmed_authors":["Sertorio M","Juchaux M","Sanchez-Garcia M","Gilbert C","Kolmel EG","Luna-Vega V","Espenon J","Roncali L","Prezado Y","Acuna-Perez MI"],"additional_accession":[]},"is_claimable":false,"name":"Mini-GRID enhances survival and reduces toxicity in an orthotopic murine model of oral squamous cell carcinoma: A proof-of-concept study.","description":"Background and purpose
Oral squamous cell carcinoma (OSCC) remains a major clinical challenge, with limited therapeutic options and poor outcomes. Among the emerging approaches to address this unmet need, spatially fractionated radiotherapy (SFRT) using mini-GRID patterns has emerged as a promising approach, delivering high radiation doses through narrowly collimated beamlets that spare intervening normal tissue and may enhance the therapeutic index. This study evaluated the efficacy and safety of mini-GRID RT in an orthotopic, syngeneic murine model of OSCC.Materials and methods
C57BL/6 mice bearing MOC1 tumors were randomized to receive conventional radiotherapy (conv-RT; 20 Gy), mini-GRID RT (20 Gy average dose), or no treatment. Endpoints included survival, tumor growth","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-06-12T04:54:26.555Z","creation":"2026-06-12T03:08:06.879Z"},"accession":"S-EPMC12804384","cross_references":{"pubmed":["41552761"],"doi":["10.1016/j.ctro.2025.101101"]}}