biostudies-literatureUnknown17(1)Blessing A<h4>Background</h4>Several studies have explored whether tobacco consumption is associated with the histologic growth patterns of pulmonary adenocarcinomas, and whether these patterns influence prognosis. However, findings have remained ambiguous. This study aimed at further exploring these associations in a larger cohort, enhancing precision compared to previous studies by assessing growth patterns on digitalized slides.<h4>Methods</h4>Resection specimens from 196 patients with pulmonary adenocarcinoma were retrospectively assessed and categorized. Where available, up to three tumour bearing H&E stained slides were digitized. Growth patterns were quantitatively assessed and categorized based on these digital images. Clinical and demographic data, including smoking history, were obtained fDiscover oncology92https://www.ebi.ac.uk/biostudies/studies/S-EPMC12804571biostudies-literatureTobacco smoking is associated with solid growth pattern in primary lung adenocarcinoma.PMC12804571Blessing AKayser COberndorfer FKayser GCsanadi AfalseTobacco smoking is associated with solid growth pattern in primary lung adenocarcinoma.<h4>Background</h4>Several studies have explored whether tobacco consumption is associated with the histologic growth patterns of pulmonary adenocarcinomas, and whether these patterns influence prognosis. However, findings have remained ambiguous. This study aimed at further exploring these associations in a larger cohort, enhancing precision compared to previous studies by assessing growth patterns on digitalized slides.<h4>Methods</h4>Resection specimens from 196 patients with pulmonary adenocarcinoma were retrospectively assessed and categorized. Where available, up to three tumour bearing H&E stained slides were digitized. Growth patterns were quantitatively assessed and categorized based on these digital images. Clinical and demographic data, including smoking history, were obtained f2025-01-01T00:00:00Z2025 Dec2026-06-06T15:06:38.436Z2026-06-01T03:10:55.581ZS-EPMC128045714136982810.1007/s12672-025-04187-3