{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zierfuss C"],"funding":["Bundesministerium für Digitalisierung und Wirtschaftsstandort","Christian Doppler Research Association","Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung"],"pagination":["105939"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12804612"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["<h4>Background</h4>Response prediction to immune checkpoint inhibitors (ICIs) relies on tumor-specific biomarkers, while patient-specific characteristics are underrepresented. Therefore, we explored patient-specific immunological characteristics, including peripheral monocytes, myeloid-derived suppressor cells (MDSCs), T cells, and the T-cell receptor (TCR) repertoire, to investigate associations with survival and therapy response.<h4>Patients and methods</h4>Patients with solid tumors were prospectively recruited to explore the association of absolute lymphocyte and monocyte counts, leukocyte-to-lymphocyte ratio (LLR), and monocyte-to-lymphocyte ratio (MLR) with overall survival (OS). Monocytes, MDSCs, T cells, and the TCR repertoire were characterized before therapy start (baseline) and,"],"journal":["ESMO open"],"pubmed_title":["Predictive potential of patient-specific immunological characteristics in solid cancers: circulating monocytes, myeloid-derived suppressor cells, T cells, and the T-cell receptor repertoire."],"pmcid":["PMC12804612"],"funding_grant_id":["CD10271101"],"pubmed_authors":["Sunder-Plassmann V","Furtner J","Ay C","Heller G","Dobrovits N","Starzer AM","Korpan M","Wolfsberg J","Preusser M","Fendl B","Grohmannova M","Berghoff AS","Berger JM","Gottmann L","Kleinberger M","Furst J","Tomasich E","Zierfuss C","Niederdorfer B","Kohl L","Solano Henao I","Sybock K","Schedl J","Vladic N"],"additional_accession":[]},"is_claimable":false,"name":"Predictive potential of patient-specific immunological characteristics in solid cancers: circulating monocytes, myeloid-derived suppressor cells, T cells, and the T-cell receptor repertoire.","description":"<h4>Background</h4>Response prediction to immune checkpoint inhibitors (ICIs) relies on tumor-specific biomarkers, while patient-specific characteristics are underrepresented. Therefore, we explored patient-specific immunological characteristics, including peripheral monocytes, myeloid-derived suppressor cells (MDSCs), T cells, and the T-cell receptor (TCR) repertoire, to investigate associations with survival and therapy response.<h4>Patients and methods</h4>Patients with solid tumors were prospectively recruited to explore the association of absolute lymphocyte and monocyte counts, leukocyte-to-lymphocyte ratio (LLR), and monocyte-to-lymphocyte ratio (MLR) with overall survival (OS). Monocytes, MDSCs, T cells, and the TCR repertoire were characterized before therapy start (baseline) and,","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-13T05:27:07.042Z","creation":"2026-06-13T03:09:06.137Z"},"accession":"S-EPMC12804612","cross_references":{"pubmed":["41478086"],"doi":["10.1016/j.esmoop.2025.105939"]}}