biostudies-literatureZierfuss CBundesministerium für Digitalisierung und WirtschaftsstandortChristian Doppler Research AssociationÖsterreichische Nationalstiftung für Forschung, Technologie und Entwicklung105939https://www.ebi.ac.uk/biostudies/studies/S-EPMC12804612biostudies-literatureUnknown11(1)<h4>Background</h4>Response prediction to immune checkpoint inhibitors (ICIs) relies on tumor-specific biomarkers, while patient-specific characteristics are underrepresented. Therefore, we explored patient-specific immunological characteristics, including peripheral monocytes, myeloid-derived suppressor cells (MDSCs), T cells, and the T-cell receptor (TCR) repertoire, to investigate associations with survival and therapy response.<h4>Patients and methods</h4>Patients with solid tumors were prospectively recruited to explore the association of absolute lymphocyte and monocyte counts, leukocyte-to-lymphocyte ratio (LLR), and monocyte-to-lymphocyte ratio (MLR) with overall survival (OS). Monocytes, MDSCs, T cells, and the TCR repertoire were characterized before therapy start (baseline) and,ESMO openPredictive potential of patient-specific immunological characteristics in solid cancers: circulating monocytes, myeloid-derived suppressor cells, T cells, and the T-cell receptor repertoire.PMC12804612CD10271101Sunder-Plassmann VFurtner JAy CHeller GDobrovits NStarzer AMKorpan MWolfsberg JPreusser MFendl BGrohmannova MBerghoff ASBerger JMGottmann LKleinberger MFurst JTomasich EZierfuss CNiederdorfer BKohl LSolano Henao ISybock KSchedl JVladic NfalsePredictive potential of patient-specific immunological characteristics in solid cancers: circulating monocytes, myeloid-derived suppressor cells, T cells, and the T-cell receptor repertoire.<h4>Background</h4>Response prediction to immune checkpoint inhibitors (ICIs) relies on tumor-specific biomarkers, while patient-specific characteristics are underrepresented. Therefore, we explored patient-specific immunological characteristics, including peripheral monocytes, myeloid-derived suppressor cells (MDSCs), T cells, and the T-cell receptor (TCR) repertoire, to investigate associations with survival and therapy response.<h4>Patients and methods</h4>Patients with solid tumors were prospectively recruited to explore the association of absolute lymphocyte and monocyte counts, leukocyte-to-lymphocyte ratio (LLR), and monocyte-to-lymphocyte ratio (MLR) with overall survival (OS). Monocytes, MDSCs, T cells, and the TCR repertoire were characterized before therapy start (baseline) and,2026-01-01T00:00:00Z2026 Jan2026-06-13T05:27:07.042Z2026-06-13T03:09:06.137ZS-EPMC128046124147808610.1016/j.esmoop.2025.105939