{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Meng Y"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["511"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12804904"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Key cereal crops, including wheat, rice and maize, supply nearly 50% of the world's caloric intake, with starch constituting over 70% of the grain weight. However, the regulatory mechanisms underlying starch synthesis are poorly understood. In this study, we identify a transcription factor TaPIL1-5D, which binds to the promoters of ADP-glucose pyrophosphorylase small subunit 1 (TaAGPS1a-7A), granule-bound starch synthase I (TaGBSSI-4A), and branching enzyme II b (TaBEIIb-2D). Similarly, its homologous OsPIL11 and ZmPIL1 also activate the expression of the AGPS1, BEIIb, and GBSSI, and positively regulates grain starch synthesis. TaPIL1-5D and ZmPIL1 improve grain yields in two successive years. Nine alleles of TaPIL1-5B form three distinct haplotypes (Hap1-3), while TaPIL1-5B-Hap1 is repres"],"journal":["Nature communications"],"pubmed_title":["The bHLH transcription factor PIL1 orchestrates starch synthesis in key cereal crops."],"pmcid":["PMC12804904"],"funding_grant_id":["32201698","32171924"],"pubmed_authors":["Li G","Li X","Wang P","Kang G","Du C","Cui J","Guo T","Meng Y","Zeng W","Ge Q"],"additional_accession":[]},"is_claimable":false,"name":"The bHLH transcription factor PIL1 orchestrates starch synthesis in key cereal crops.","description":"Key cereal crops, including wheat, rice and maize, supply nearly 50% of the world's caloric intake, with starch constituting over 70% of the grain weight. However, the regulatory mechanisms underlying starch synthesis are poorly understood. In this study, we identify a transcription factor TaPIL1-5D, which binds to the promoters of ADP-glucose pyrophosphorylase small subunit 1 (TaAGPS1a-7A), granule-bound starch synthase I (TaGBSSI-4A), and branching enzyme II b (TaBEIIb-2D). Similarly, its homologous OsPIL11 and ZmPIL1 also activate the expression of the AGPS1, BEIIb, and GBSSI, and positively regulates grain starch synthesis. TaPIL1-5D and ZmPIL1 improve grain yields in two successive years. Nine alleles of TaPIL1-5B form three distinct haplotypes (Hap1-3), while TaPIL1-5B-Hap1 is repres","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-11T05:28:38.311Z","creation":"2026-06-11T03:08:19.429Z"},"accession":"S-EPMC12804904","cross_references":{"pubmed":["41372211"],"doi":["10.1038/s41467-025-67200-x"]}}