{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pomar CA"],"funding":["Ministry of Health of the Czech Republic","MCIN/AEI and ERDF a way of making Europe"],"pagination":["e71452"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12805928"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(2)"],"pubmed_abstract":["Perinatal nutrition influences offspring metabolic phenotype and obesity risk. This study examines how a maternal obesogenic diet and offspring's leptin supplementation during suckling affect the metabolome in offspring adulthood, offering insights into long-term metabolic programming. Offspring of dams fed a standard diet (SD), a Western-style diet (WD) before and during gestation and lactation (WD-dams), or a WD switched to SD during lactation were supplemented throughout suckling with leptin or vehicle and then maintained on an SD post-weaning. Metabolomic analysis of plasma from offspring adult animals revealed sex-specific alterations in the relative abundance of circulating metabolites due to maternal WD. Among these, lower abundance of orotic acid in males and arginine in females em"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["Metabolomic Insights Into the Impact of a Maternal Western-Style Diet and Leptin Supplementation During Suckling on Adult Rat Offspring."],"pmcid":["PMC12805928"],"funding_grant_id":["PID2022-138140NB-I00","NU20-07-00026","PGC2018-097436-B-I00"],"pubmed_authors":["Palou M","Pico C","Pomar CA","Zouhar P","Kopecky J","Castillo P","Cajka T","Palou A","Martin-Chamorro RA"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomic Insights Into the Impact of a Maternal Western-Style Diet and Leptin Supplementation During Suckling on Adult Rat Offspring.","description":"Perinatal nutrition influences offspring metabolic phenotype and obesity risk. This study examines how a maternal obesogenic diet and offspring's leptin supplementation during suckling affect the metabolome in offspring adulthood, offering insights into long-term metabolic programming. Offspring of dams fed a standard diet (SD), a Western-style diet (WD) before and during gestation and lactation (WD-dams), or a WD switched to SD during lactation were supplemented throughout suckling with leptin or vehicle and then maintained on an SD post-weaning. Metabolomic analysis of plasma from offspring adult animals revealed sex-specific alterations in the relative abundance of circulating metabolites due to maternal WD. Among these, lower abundance of orotic acid in males and arginine in females em","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-10T05:28:09.038Z","creation":"2026-06-10T03:07:42.939Z"},"accession":"S-EPMC12805928","cross_references":{"pubmed":["41537760"],"doi":["10.1096/fj.202501729RRR"]}}