{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Monnie CM"],"funding":["NIAID NIH HHS"],"pagination":["3417-3422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12806166"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["366(16)"],"pubmed_abstract":["A scalable procedure for the synthesis of 4,6-difluorotryptophan is reported based on a deaminative coupling of a 4,6-difluorogramine with 2-benzylthio-1,5-dihydro-4<i>H</i>-imidazolone as glycine equivalent. Thus prepared 4,6-difluorotryptophan was incorporated into the C-terminal domain of the HIV-1 capsid protein (CA-CTD), and <sup>19</sup>F spectra of the 4,6-difluoro Trp CA CTD were recorded and compared to the singly fluorinated counterparts."],"journal":["Advanced synthesis & catalysis"],"pubmed_title":["Synthesis of 4,6-Difluoro-Tryptophan as a Probe for Protein &lt;sup&gt;19&lt;/sup&gt;F NMR."],"pmcid":["PMC12806166"],"funding_grant_id":["U54 AI170791"],"pubmed_authors":["Gronenborn AM","Hernandez I","Oiarbide M","Melendez-Pacheco R","Bhinderwala F","Landa A","Monnie CM","Soloshonok VA"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of 4,6-Difluoro-Tryptophan as a Probe for Protein &lt;sup&gt;19&lt;/sup&gt;F NMR.","description":"A scalable procedure for the synthesis of 4,6-difluorotryptophan is reported based on a deaminative coupling of a 4,6-difluorogramine with 2-benzylthio-1,5-dihydro-4<i>H</i>-imidazolone as glycine equivalent. Thus prepared 4,6-difluorotryptophan was incorporated into the C-terminal domain of the HIV-1 capsid protein (CA-CTD), and <sup>19</sup>F spectra of the 4,6-difluoro Trp CA CTD were recorded and compared to the singly fluorinated counterparts.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-06T13:48:24.342Z","creation":"2026-05-31T03:09:56.424Z"},"accession":"S-EPMC12806166","cross_references":{"pubmed":["41552695"],"doi":["10.1002/adsc.202400031"]}}