{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun X"],"funding":["Alliance for Lupus Research","NIAID NIH HHS","Lupus Research Alliance","National Institutes of Health","NIAMS NIH HHS","NIH HHS"],"pagination":["867-875"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12807450"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(7)"],"pubmed_abstract":["<h4>Objective</h4>Photosensitivity occurs in ~75% of patients with lupus. Although UV light radiation (UVR) stimulates type I interferon (IFN-I) in the skin, how UVR-induced skin inflammation leads to downstream effects is poorly understood. Tissue inflammation causes dendritic cells (DCs) to migrate from organs to draining lymph nodes (dLN), including a recently identified inflammatory conventional DC subset (inf cDC2) that are potent antigen-presenting cells. To explore links between UVR and the early immune response, we examined DC and lymphocyte subset migration to dLN in normal and lupus-prone mouse strains as well as the role of IFN-I.<h4>Methods</h4>Mice received a single dose of UV (500 mJ/cm<sup>2</sup>) on the dorsal skin. Brachial and inguinal dLN were harvested at one or two da"],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pubmed_title":["Induction of Type I Interferon-Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes by UV Light Exposure."],"pmcid":["PMC12807450"],"funding_grant_id":["R01 AI134713","T32 AR007108","R01AI134713","R21 AR077842","T32AR007108","R21AR077842"],"pubmed_authors":["Elkon KB","Gerner M","Sun X","Chao JL"],"additional_accession":[]},"is_claimable":false,"name":"Induction of Type I Interferon-Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes by UV Light Exposure.","description":"<h4>Objective</h4>Photosensitivity occurs in ~75% of patients with lupus. Although UV light radiation (UVR) stimulates type I interferon (IFN-I) in the skin, how UVR-induced skin inflammation leads to downstream effects is poorly understood. Tissue inflammation causes dendritic cells (DCs) to migrate from organs to draining lymph nodes (dLN), including a recently identified inflammatory conventional DC subset (inf cDC2) that are potent antigen-presenting cells. To explore links between UVR and the early immune response, we examined DC and lymphocyte subset migration to dLN in normal and lupus-prone mouse strains as well as the role of IFN-I.<h4>Methods</h4>Mice received a single dose of UV (500 mJ/cm<sup>2</sup>) on the dorsal skin. Brachial and inguinal dLN were harvested at one or two da","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-10T05:28:03.025Z","creation":"2026-06-10T03:07:41.587Z"},"accession":"S-EPMC12807450","cross_references":{"pubmed":["39800946"],"doi":["10.1002/art.43108"]}}