biostudies-literatureSun XAlliance for Lupus ResearchNIAID NIH HHSLupus Research AllianceNational Institutes of HealthNIAMS NIH HHSNIH HHS867-875https://www.ebi.ac.uk/biostudies/studies/S-EPMC12807450biostudies-literatureUnknown77(7)<h4>Objective</h4>Photosensitivity occurs in ~75% of patients with lupus. Although UV light radiation (UVR) stimulates type I interferon (IFN-I) in the skin, how UVR-induced skin inflammation leads to downstream effects is poorly understood. Tissue inflammation causes dendritic cells (DCs) to migrate from organs to draining lymph nodes (dLN), including a recently identified inflammatory conventional DC subset (inf cDC2) that are potent antigen-presenting cells. To explore links between UVR and the early immune response, we examined DC and lymphocyte subset migration to dLN in normal and lupus-prone mouse strains as well as the role of IFN-I.<h4>Methods</h4>Mice received a single dose of UV (500 mJ/cm²) on the dorsal skin. Brachial and inguinal dLN were harvested at one or two daArthritis & rheumatology (Hoboken, N.J.)Induction of Type I Interferon-Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes by UV Light Exposure.PMC12807450R01 AI134713T32 AR007108R01AI134713R21 AR077842T32AR007108R21AR077842Elkon KBGerner MSun XChao JLfalseInduction of Type I Interferon-Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes by UV Light Exposure.<h4>Objective</h4>Photosensitivity occurs in ~75% of patients with lupus. Although UV light radiation (UVR) stimulates type I interferon (IFN-I) in the skin, how UVR-induced skin inflammation leads to downstream effects is poorly understood. Tissue inflammation causes dendritic cells (DCs) to migrate from organs to draining lymph nodes (dLN), including a recently identified inflammatory conventional DC subset (inf cDC2) that are potent antigen-presenting cells. To explore links between UVR and the early immune response, we examined DC and lymphocyte subset migration to dLN in normal and lupus-prone mouse strains as well as the role of IFN-I.<h4>Methods</h4>Mice received a single dose of UV (500 mJ/cm²) on the dorsal skin. Brachial and inguinal dLN were harvested at one or two da2025-01-01T00:00:00Z2025 Jul2026-06-10T05:28:03.025Z2026-06-10T03:07:41.587ZS-EPMC128074503980094610.1002/art.43108