{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(1)"],"submitter":["Vazquez de Vasquez MG"],"funding":["IR Medtek LLC"],"pubmed_abstract":["A fast mid-infrared spectral probe was used to record infrared (IR) spectra of fresh skin tissue removed from patients with biopsy-proven keratinocytic cancer (KC) during Mohs surgery. A 150-patient library of IR spectral data was obtained to see if KC on the epidermal side (outside) of tissue samples can be differentiated from adjacent nonmalignant tissue and normal skin. A linear support vector machine model minimized overtraining predicting the contributions to decisions at each step in the spectrum. Training with an equal cost for KC and nontumor cases samples demonstrated a KC sensitivity of 93% ± 5% and specificity 82% ± 6% (threefold testing esd) on the full library. Success in this test problem warrants future studies to see if differentiation of melanoma from benign melanocytic as"],"journal":["Journal of biophotonics"],"pagination":["e70226"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12807626"],"repository":["biostudies-literature"],"pubmed_title":["Ex Vivo Assessment of Keratinocytic Carcinomas Using a Fast Mid-Infrared Probe."],"pmcid":["PMC12807626"],"pubmed_authors":["Siegle R","Casey AS","Cusick A","Coe JV","Hitchcock CL","Vazquez de Vasquez MG","Bradley RC"],"additional_accession":[]},"is_claimable":false,"name":"Ex Vivo Assessment of Keratinocytic Carcinomas Using a Fast Mid-Infrared Probe.","description":"A fast mid-infrared spectral probe was used to record infrared (IR) spectra of fresh skin tissue removed from patients with biopsy-proven keratinocytic cancer (KC) during Mohs surgery. A 150-patient library of IR spectral data was obtained to see if KC on the epidermal side (outside) of tissue samples can be differentiated from adjacent nonmalignant tissue and normal skin. A linear support vector machine model minimized overtraining predicting the contributions to decisions at each step in the spectrum. Training with an equal cost for KC and nontumor cases samples demonstrated a KC sensitivity of 93% ± 5% and specificity 82% ± 6% (threefold testing esd) on the full library. Success in this test problem warrants future studies to see if differentiation of melanoma from benign melanocytic as","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-10T05:15:10.854Z","creation":"2026-06-10T03:07:29.13Z"},"accession":"S-EPMC12807626","cross_references":{"pubmed":["41539695"],"doi":["10.1002/jbio.70226"]}}