biostudies-literatureYan YNebraska Tobacco Settlement Biomedical Research Enhancement FundsUnited States Department of AgricultureNational Institutes of HealthNIH HHSNIGMS NIH HHSD555-D563https://www.ebi.ac.uk/biostudies/studies/S-EPMC12807701biostudies-literatureUnknown54(D1)CAZymes (Carbohydrate Active EnZymes) play key metabolic functions in human gut microbiomes (HGM). Genes of glycan degrading CAZymes often form physically linked CAZyme Gene Clusters (CGCs) in gut bacterial genomes. Here we developed dbCAN-HGM (https://pro.unl.edu/dbCAN_HGM), a comprehensive data repository for human gut bacterial CGCs and CAZymes. dbCAN-HGM has the following unique features: (i) 121 883 CGCs are identified in 6031 high-quality species-level representative metagenome assembled genomes (MAGs), from a wide range of human populations, especially the under-studied African population; (ii) Each CGC page includes metagenomic read mapping results from different diets (vegan, vegetarian, omnivore, flexitarian) and disease statuses (ulcerative colitis [UC and Crohns disease), with Nucleic acids researchdbCAN-HGM: CAZyme gene clusters in gut microbiomes of diverse human populations.PMC12807701R03OD03997958-8042-3-076R01GM140370R03 OD039979R01 GM140370Yin YShanmugam NRSAkresi JYan YPatel RSKRfalsedbCAN-HGM: CAZyme gene clusters in gut microbiomes of diverse human populations.CAZymes (Carbohydrate Active EnZymes) play key metabolic functions in human gut microbiomes (HGM). Genes of glycan degrading CAZymes often form physically linked CAZyme Gene Clusters (CGCs) in gut bacterial genomes. Here we developed dbCAN-HGM (https://pro.unl.edu/dbCAN_HGM), a comprehensive data repository for human gut bacterial CGCs and CAZymes. dbCAN-HGM has the following unique features: (i) 121 883 CGCs are identified in 6031 high-quality species-level representative metagenome assembled genomes (MAGs), from a wide range of human populations, especially the under-studied African population; (ii) Each CGC page includes metagenomic read mapping results from different diets (vegan, vegetarian, omnivore, flexitarian) and disease statuses (ulcerative colitis [UC and Crohns disease), with 2026-01-01T00:00:00Z2026 Jan2026-06-01T03:12:46.034Z2026-06-01T03:07:03.432ZS-EPMC128077014126309810.1093/nar/gkaf1185