biostudies-literatureRagueneau EOpen TargetsEuropean Bioinformatics InstituteNHGRI NIH HHSNational Institutes of HealthConnected Minds PrototypingNIH HHSD673-D681https://www.ebi.ac.uk/biostudies/studies/S-EPMC12807730biostudies-literatureUnknown54(D1)The Reactome Knowledgebase (https://reactome.org) is a freely accessible, expert-curated, open-source, and open-data resource that describes human biology in molecular detail. It spans normal physiology as well as disease mechanisms, including the impact of genetic variation and drug action. Reactome content is continuously expanded and revised, with automated workflows now monitoring retracted publications to maintain data integrity. To meet the needs of a growing user base, Reactome has launched a redesigned Angular-based interface with enhanced accessibility, modular architecture, and a hierarchy of visualization tools: ReacFoam for global pathway overviews, enhanced high-level diagrams for intuitive navigation, and redesigned entity level views (ELVs) enriched with chemical structures,Nucleic acids researchThe Reactome Knowledgebase 2026.PMC12807730U24HG011851U24 HG012198U24HG012198-02S1U24HG012198U24 HG011851Sevilla CStephan RWu GMay BStein LShamovsky VRothfels KGillespie MHogue GFJGong CWright ARagueneau EMohammadi HSinquin PHermjakob HWeiser JPetryszak RMilacic MMatthews LGriss JBeavers DTiwari KLi NTGrentner AD'Eustachio PfalseThe Reactome Knowledgebase 2026.The Reactome Knowledgebase (https://reactome.org) is a freely accessible, expert-curated, open-source, and open-data resource that describes human biology in molecular detail. It spans normal physiology as well as disease mechanisms, including the impact of genetic variation and drug action. Reactome content is continuously expanded and revised, with automated workflows now monitoring retracted publications to maintain data integrity. To meet the needs of a growing user base, Reactome has launched a redesigned Angular-based interface with enhanced accessibility, modular architecture, and a hierarchy of visualization tools: ReacFoam for global pathway overviews, enhanced high-level diagrams for intuitive navigation, and redesigned entity level views (ELVs) enriched with chemical structures,2026-01-01T00:00:00Z2026 Jan2026-07-15T06:34:57.246Z2026-06-30T03:21:29.248ZS-EPMC128077304125115010.1093/nar/gkaf1223