biostudies-literatureSanou GScientific Research National CenterInstitut du développement et des ressources en informatique scientifique (IDRIS)University of MontpellierScientific Research National Center (CNRS)Immun4Cure University Hospital Institute “Institute for innovative immunotherapies in autoimmune diseases”Institut Universitaire de FranceImmun4Cure University Hospital Institute "Institute for innovative immunotherapies in autoimmune diseases"Institut du développement et des ressources en informatique scientifiqueGENCID1119-D1132https://www.ebi.ac.uk/biostudies/studies/S-EPMC12807764biostudies-literatureUnknown54(D1)IMGT®, the international ImMunoGeneTics information system®, has advanced its comprehensive platform for the analysis of immunoglobulin (IG) and T-cell receptor (TR) genes through the development of new automated and scalable tools. This article presents major updates aligned with IMGT's three axes of research. Axis I introduces dynamic resources such as IMGT/GeneTables, IMGT/AssemblyComparison, IMGT/CDRLengths, IMGT/MultiGenomeViewer, enabling real-time access to annotated genomic data, and IMGT/StatAssembly to assess quality of IG/TR loci in assemblies. Axis II enhances repertoire analysis with a redesigned IMGT/GeneFrequency tool and new customization features in IMGT/V-QUEST, supporting flexible exploration of IG and TR gene expression. Axis III improves the accurate prediction of peptNucleic acids researchIMGT® at scale: FAIR, dynamic, and automated tools for immune locus analysis.PMC128077640360292030 / ANR-23-IHUA-0009Sanou GZeitoun GGeorga MManso TEidi MAbdollahi NGiudicelli VDuroux PBatool SVaillant ACroze MDebbagh CSideri IKushwaha APapadaki AFolch GJabado-Michaloud JKossida SSamadova TGrand FfalseIMGT® at scale: FAIR, dynamic, and automated tools for immune locus analysis.IMGT®, the international ImMunoGeneTics information system®, has advanced its comprehensive platform for the analysis of immunoglobulin (IG) and T-cell receptor (TR) genes through the development of new automated and scalable tools. This article presents major updates aligned with IMGT's three axes of research. Axis I introduces dynamic resources such as IMGT/GeneTables, IMGT/AssemblyComparison, IMGT/CDRLengths, IMGT/MultiGenomeViewer, enabling real-time access to annotated genomic data, and IMGT/StatAssembly to assess quality of IG/TR loci in assemblies. Axis II enhances repertoire analysis with a redesigned IMGT/GeneFrequency tool and new customization features in IMGT/V-QUEST, supporting flexible exploration of IG and TR gene expression. Axis III improves the accurate prediction of pept2026-01-01T00:00:00Z2026 Jan2026-05-31T03:16:04.063Z2026-05-31T03:10:15.601ZS-EPMC128077644109193010.1093/nar/gkaf1024