{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Capel HL"],"pubmed_abstract":["In August 2024, the World Health Organization declared the mpox orthopoxvirus to be a Public Health Emergency of International Concern for the second time in three years, emphasising the need for continued studies into its microbiology and potential therapeutic interventions. Here, we presented the Orthopoxvirus Antibody Database (Pox-AbDab), a repository of data on antibodies known to bind or neutralise viruses from the same genus as mpox (https://opig.stats.ox.ac.uk/webapps/poxabdab). Beyond standardising and centralising the data, we highlighted challenges in translating knowledge across orthopoxviruses, such as the absence of a function-based nomenclature for virion surface antigens. We also performed an exploratory analysis of the known orthopoxvirus-binding antibody landscape, highli"],"journal":["Frontiers in immunology"],"pagination":["1698441"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12808477"],"repository":["biostudies-literature"],"pubmed_title":["Pox-AbDab: the orthopoxvirus antibody database."],"pmcid":["PMC12808477"],"pubmed_authors":["Wang EJD","Capel HL","Deane CM","Williams BH","Raybould MIJ"],"additional_accession":[]},"is_claimable":false,"name":"Pox-AbDab: the orthopoxvirus antibody database.","description":"In August 2024, the World Health Organization declared the mpox orthopoxvirus to be a Public Health Emergency of International Concern for the second time in three years, emphasising the need for continued studies into its microbiology and potential therapeutic interventions. Here, we presented the Orthopoxvirus Antibody Database (Pox-AbDab), a repository of data on antibodies known to bind or neutralise viruses from the same genus as mpox (https://opig.stats.ox.ac.uk/webapps/poxabdab). Beyond standardising and centralising the data, we highlighted challenges in translating knowledge across orthopoxviruses, such as the absence of a function-based nomenclature for virion surface antigens. We also performed an exploratory analysis of the known orthopoxvirus-binding antibody landscape, highli","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T15:56:57.504Z","creation":"2026-06-02T03:10:34.255Z"},"accession":"S-EPMC12808477","cross_references":{"pubmed":["41550936"],"doi":["10.3389/fimmu.2025.1698441"]}}