{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Salzmann RJS"],"pubmed_abstract":["Human-derived biomaterials offer several advantages over animal-derived or synthetic alternatives, including improved biocompatibility, ethical acceptability, sustainability, and clinical translatability. Here we present new applications of human placenta-derived materials - specifically HUMAN PLACENTA substrate, collagen type-I, and Laminin-111 - as 2D coating materials and 3D matrices for the cultivation of spheroids and adherent cells. Collagen type-I coatings supported colorectal cancer spheroid formation without the need for growth-factor supplementation. Lm-111 significantly enhanced NIH3T3 fibroblast adhesion compared with poly-L-lysine and rat-tail collagen type-I, performing comparably to bovine fibronectin. In a transwell blood-brain barrier model, HUMAN PLACENTA substrate coatin"],"journal":["Frontiers in bioengineering and biotechnology"],"pagination":["1676369"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12808481"],"repository":["biostudies-literature"],"pubmed_title":["New applications of sustainable, scalable, standardized, and cost-effective human biomaterials for cell-based assays, tissue engineering, and regenerative medicine."],"pmcid":["PMC12808481"],"pubmed_authors":["Moroni L","Salzmann RJS","Kigili S","Neuhaus W","Hackethal J","Egger G","Prado-Lopez S","Domazet S","Brachner A"],"additional_accession":[]},"is_claimable":false,"name":"New applications of sustainable, scalable, standardized, and cost-effective human biomaterials for cell-based assays, tissue engineering, and regenerative medicine.","description":"Human-derived biomaterials offer several advantages over animal-derived or synthetic alternatives, including improved biocompatibility, ethical acceptability, sustainability, and clinical translatability. Here we present new applications of human placenta-derived materials - specifically HUMAN PLACENTA substrate, collagen type-I, and Laminin-111 - as 2D coating materials and 3D matrices for the cultivation of spheroids and adherent cells. Collagen type-I coatings supported colorectal cancer spheroid formation without the need for growth-factor supplementation. Lm-111 significantly enhanced NIH3T3 fibroblast adhesion compared with poly-L-lysine and rat-tail collagen type-I, performing comparably to bovine fibronectin. In a transwell blood-brain barrier model, HUMAN PLACENTA substrate coatin","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-12T04:54:09.722Z","creation":"2026-06-12T03:08:02.546Z"},"accession":"S-EPMC12808481","cross_references":{"pubmed":["41550371"],"doi":["10.3389/fbioe.2025.1676369"]}}