{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Klumpen L"],"funding":["Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)","Deutsche Forschungsgemeinschaft (German Research Foundation)"],"pagination":["598"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12808737"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Oats have various positive effects on human health, but the underlying mechanisms are not fully understood. To identify oat-microbiome-host interactions contributing to metabolic improvements, we conducted two randomized controlled dietary interventions in parallel-design in individuals with metabolic syndrome, comparing a short-term, high-dose and a six-week, moderate oat intake with respective controls (DRKS00022169). Both oat diets lead to an increase in plasma ferulic acid (0.64 [0.26, 1.02], P = 0.002; 0.55 [0.21, 0.89], P = 0.003), while the high-dose oat-diet also increased dihydroferulic acid (1.23 [0.44, 2.01], P = 0.003). Here we show that microbial phenolic metabolites are driving factors for the cholesterol-lowering effect of oats, which might be of relevance since short-term, "],"journal":["Nature communications"],"pubmed_title":["Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial."],"pmcid":["PMC12808737"],"funding_grant_id":["432325352 - SFB 1454, EXC 2151-390873048","432325352 - SFB 1454","01EA1707"],"pubmed_authors":["Wiemann V","Hasenauer J","Stoffel-Wagner B","Burgdorf S","Schlautmann L","Seel W","Klumpen L","Coenen M","Thiele C","Mantri A","Stehle P","Philipps M","Weinhold L","Fließwasser T","Yaghmour MH","Simon MC"],"additional_accession":[]},"is_claimable":false,"name":"Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial.","description":"Oats have various positive effects on human health, but the underlying mechanisms are not fully understood. To identify oat-microbiome-host interactions contributing to metabolic improvements, we conducted two randomized controlled dietary interventions in parallel-design in individuals with metabolic syndrome, comparing a short-term, high-dose and a six-week, moderate oat intake with respective controls (DRKS00022169). Both oat diets lead to an increase in plasma ferulic acid (0.64 [0.26, 1.02], P = 0.002; 0.55 [0.21, 0.89], P = 0.003), while the high-dose oat-diet also increased dihydroferulic acid (1.23 [0.44, 2.01], P = 0.003). Here we show that microbial phenolic metabolites are driving factors for the cholesterol-lowering effect of oats, which might be of relevance since short-term, ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T15:40:28.81Z","creation":"2026-06-02T03:09:17.457Z"},"accession":"S-EPMC12808737","cross_references":{"pubmed":["41535271"],"doi":["10.1038/s41467-026-68303-9"]}}