{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["59"],"submitter":["Zhang X"],"pubmed_abstract":["Bacterial infection, peri-implant inflammation, and poor osseointegration are primary causes of failure in titanium (Ti)-based implants. Surface functionalization provides a simple and effective strategy to overcome these challenges. In this study, we developed a multifunctional coating based on porous graphdiyne (GDY) nanofilm loaded with shikonin (Skn). GDY was synthesized on Ti surfaces <i>via</i> a copper-catalyzed reaction to form a porous nanostructure. Following Skn loading, a composite layer of tannic acid (TA) and poly (<i>N</i>-isopropylacrylamide) (pNIPAM) was applied, resulting in the Ti-GDY@Skn-TP system. Upon near-infrared (NIR) irradiation, the GDY coating induced localized photothermal effects sufficient to eradicate bacteria. Concurrently, the thermo-responsive release of "],"journal":["Bioactive materials"],"pagination":["629-641"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12808909"],"repository":["biostudies-literature"],"pubmed_title":["Shikonin-loaded porous graphdiyne nanofilm on titanium surface for enhanced antibacterial activity and osseointegration."],"pmcid":["PMC12808909"],"pubmed_authors":["Murugesan S","Xu L","Liu Y","Xu K","Kang ET","Zhang X","Barao VAR","Rao X","Han Y","Li K"],"additional_accession":[]},"is_claimable":false,"name":"Shikonin-loaded porous graphdiyne nanofilm on titanium surface for enhanced antibacterial activity and osseointegration.","description":"Bacterial infection, peri-implant inflammation, and poor osseointegration are primary causes of failure in titanium (Ti)-based implants. Surface functionalization provides a simple and effective strategy to overcome these challenges. In this study, we developed a multifunctional coating based on porous graphdiyne (GDY) nanofilm loaded with shikonin (Skn). GDY was synthesized on Ti surfaces <i>via</i> a copper-catalyzed reaction to form a porous nanostructure. Following Skn loading, a composite layer of tannic acid (TA) and poly (<i>N</i>-isopropylacrylamide) (pNIPAM) was applied, resulting in the Ti-GDY@Skn-TP system. Upon near-infrared (NIR) irradiation, the GDY coating induced localized photothermal effects sufficient to eradicate bacteria. Concurrently, the thermo-responsive release of ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 May","modification":"2026-06-11T05:27:00.618Z","creation":"2026-06-11T03:08:02.179Z"},"accession":"S-EPMC12808909","cross_references":{"pubmed":["41551774"],"doi":["10.1016/j.bioactmat.2025.12.055"]}}