{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(1)"],"submitter":["Kravtsova O"],"pubmed_abstract":["Malonyl-CoA decarboxylase (MCD), encoded by <i>Mlycd</i>, plays a critical role in regulating malonyl-CoA levels, fatty acid oxidation, and glucose metabolism. To investigate the systemic effects of <i>Mlycd</i> deficiency, we generated a genetically modified rat model with partial loss of <i>Mlycd</i>. Due to high preweaning mortality in homozygous mutants, we focused on heterozygous and wild-type animals for cross-tissue targeted proteomic and metabolomic analyses. Alterations in metabolic and stress-related pathways were observed across the heart, kidney, liver, plasma, and urine. Enrichment of oxidative phosphorylation, fatty acid metabolism, immune responses, and autophagy-related signaling was noted. Elevated levels of oxidative stress-related proteins and disrupted autophagy regulat"],"journal":["iScience"],"pagination":["114505"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12808911"],"repository":["biostudies-literature"],"pubmed_title":["MCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats."],"pmcid":["PMC12808911"],"pubmed_authors":["Rinschen MM","Levchenko V","Tiwari R","Zietara A","Sharp TE","Staruschenko A","Dissanayake LV","Palygin O","Bohovyk R","Tan Y","Van TT","Geurts AM","Kravtsova O","Kovalenko E"],"additional_accession":[]},"is_claimable":false,"name":"MCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats.","description":"Malonyl-CoA decarboxylase (MCD), encoded by <i>Mlycd</i>, plays a critical role in regulating malonyl-CoA levels, fatty acid oxidation, and glucose metabolism. To investigate the systemic effects of <i>Mlycd</i> deficiency, we generated a genetically modified rat model with partial loss of <i>Mlycd</i>. Due to high preweaning mortality in homozygous mutants, we focused on heterozygous and wild-type animals for cross-tissue targeted proteomic and metabolomic analyses. Alterations in metabolic and stress-related pathways were observed across the heart, kidney, liver, plasma, and urine. Enrichment of oxidative phosphorylation, fatty acid metabolism, immune responses, and autophagy-related signaling was noted. Elevated levels of oxidative stress-related proteins and disrupted autophagy regulat","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T16:01:29.591Z","creation":"2026-06-02T03:09:40.036Z"},"accession":"S-EPMC12808911","cross_references":{"pubmed":["41550752"],"doi":["10.1016/j.isci.2025.114505"]}}