biostudies-literatureUnknown21(1)Ali NT<h4>Objective</h4>This study investigated lunar-phase-dependent variations in hematological and immune parameters to empirically validate traditional Islamic recommendations for performing hijama (wet cupping) during specific mid-Hijri lunar days (17th-21st).<h4>Methods</h4>A total of 258 healthy adults (200 men and 58 women) from Ad'Dla Governorate underwent morning venipuncture (0700-0900, ≥8 h fasting) during the new moon (1st-5th) and full moon (17th-21st) phases. Complete blood counts and coagulation profiles were analyzed with automated systems. Hydration was standardized (500 ml water 1 h pre-sampling), and laboratory technicians were blinded to phase assignments. Statistical analysis included paired t-tests and ANOVA with α = 0.05.<h4>Results</h4>Platelets increased by 5.9% in men Journal of Taibah University Medical Sciences33-40https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809067biostudies-literatureLunar synchronization of hemostasis and immunity validates prophetic timing of hijama therapy: A multicenter study from Yemen.PMC12809067Mohammed OMohammed NJamal ASaleh MAli NTNabil SMohammed KAbdullah RSDahan BAdel AAhmed IHamid SKhalid YAhmed FAbdualkareem AAbdullah TfalseLunar synchronization of hemostasis and immunity validates prophetic timing of hijama therapy: A multicenter study from Yemen.<h4>Objective</h4>This study investigated lunar-phase-dependent variations in hematological and immune parameters to empirically validate traditional Islamic recommendations for performing hijama (wet cupping) during specific mid-Hijri lunar days (17th-21st).<h4>Methods</h4>A total of 258 healthy adults (200 men and 58 women) from Ad'Dla Governorate underwent morning venipuncture (0700-0900, ≥8 h fasting) during the new moon (1st-5th) and full moon (17th-21st) phases. Complete blood counts and coagulation profiles were analyzed with automated systems. Hydration was standardized (500 ml water 1 h pre-sampling), and laboratory technicians were blinded to phase assignments. Statistical analysis included paired t-tests and ANOVA with α = 0.05.<h4>Results</h4>Platelets increased by 5.9% in men 2026-01-01T00:00:00Z2026 Feb2026-06-10T05:23:47.351Z2026-06-10T03:07:29.824ZS-EPMC128090674155024210.1016/j.jtumed.2025.12.004