{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["123"],"submitter":["Cappadona C"],"funding":["Governo Italiano Ministero dell&amp;apos;Istruzione dell&amp;apos;Università e della Ricerca"],"pubmed_abstract":["<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected over 26 million individuals in Italy, resulting in ∼200,000 COVID-19-related deaths. Unravelling host genetic factors underlying disease severity is key to understanding progression mechanisms.<h4>Methods</h4>We applied multi-omics approaches to investigate genetic susceptibility to COVID-19 severity in the Italian population. We combined an exome-wide case-control study of rare germline variants (215 severe/critically ill patients vs 1755 controls) with transcriptomic (differential gene expression and alternative splicing) analyses of 59 hospitalised patients to identify signatures associated with severe respiratory outcomes (ICU admission).<h4>Findings</h4>Rare variant analysis revealed significant a"],"journal":["EBioMedicine"],"pagination":["106111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809084"],"repository":["biostudies-literature"],"pubmed_title":["Multi-omics identifies oxidative stress, prothrombotic pathways, and lactoperoxidase variants as key factors in COVID-19 severity."],"pmcid":["PMC12809084"],"pubmed_authors":["Paraboschi EM","Asselta R","Cappadona C","Rimoldi V","Cardamone G","Tettamanzi F","Mantovani A","Solda G"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omics identifies oxidative stress, prothrombotic pathways, and lactoperoxidase variants as key factors in COVID-19 severity.","description":"<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected over 26 million individuals in Italy, resulting in ∼200,000 COVID-19-related deaths. Unravelling host genetic factors underlying disease severity is key to understanding progression mechanisms.<h4>Methods</h4>We applied multi-omics approaches to investigate genetic susceptibility to COVID-19 severity in the Italian population. We combined an exome-wide case-control study of rare germline variants (215 severe/critically ill patients vs 1755 controls) with transcriptomic (differential gene expression and alternative splicing) analyses of 59 hospitalised patients to identify signatures associated with severe respiratory outcomes (ICU admission).<h4>Findings</h4>Rare variant analysis revealed significant a","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T07:45:30.871Z","creation":"2026-07-01T03:08:01.369Z"},"accession":"S-EPMC12809084","cross_references":{"pubmed":["41500120"],"doi":["10.1016/j.ebiom.2025.106111"]}}