{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bischoff AC"],"funding":["National Cancer Institute (NCI)","Biomedical Laboratory Research and Development, VA Office of Research and Development (BLRD)","Association of VA Surgeons","BLRD VA","American Surgical Association Foundation (ASAF)","NIDDK NIH HHS","Association for Academic Surgery (AAS)","National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NCI NIH HHS","American College of Gastroenterology (ACG)"],"pagination":["331-348"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809115"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["86(2)"],"pubmed_abstract":["Cancer-associated fibroblasts (CAF) are a prevalent cell population in the microenvironment of pancreatic cancer. The pancreas harbors diverse resident cell populations that can differentiate into CAFs, and the cell of origin might contribute to CAF heterogeneity. Expression of the transcription factor Wilms tumor 1 (WT1) marks mesothelial cells as well as a transcriptionally distinct population of fibroblasts in the normal pancreas. WT1 expression also identifies a population of CAFs in both human and mouse pancreatic cancers. In this study, we investigated the contribution of WT1+ mesenchymal cells to CAF populations and evaluated the functional role of WT1+ stromal cells in pancreatic cancer. Lineage tracing revealed that WT1+ cells expand in pancreatic cancer, giving rise to a populati"],"journal":["Cancer research"],"pubmed_title":["Wilms Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression."],"pmcid":["PMC12809115"],"funding_grant_id":["IK2 BX005875","5R01DK128102","F31 CA284505","R01 CA290780","U01 CA274154","R01-CA275182","R37 CA262209","I5I01BX005777","U54 CA274371","I01 BX005777","R01-CA271510","IK2BX005875","T32 DK094775","R01 CA275182","R01 CA268426","P30 CA046592","R01 CA271510","T32-DK094775","T32 CA009676","F31-CA284505","U54CA274371","R01 DK128102","T32-CA009676","U01CA274154","R01CA290780","R01-CA268426","R37CA262209"],"pubmed_authors":["Bischoff AC","Watkoske HR","Bednar F","Green LM","Pasca di Magliano M","Yan W","denDekker AD","Olivei AC","The S","Brown K","Carpenter ES","Zhang Y","Lasse Opsahl EL","Espinoza CE","Frankel TL","Shi J","Rai R","Okoye JO"],"additional_accession":[]},"is_claimable":false,"name":"Wilms Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression.","description":"Cancer-associated fibroblasts (CAF) are a prevalent cell population in the microenvironment of pancreatic cancer. The pancreas harbors diverse resident cell populations that can differentiate into CAFs, and the cell of origin might contribute to CAF heterogeneity. Expression of the transcription factor Wilms tumor 1 (WT1) marks mesothelial cells as well as a transcriptionally distinct population of fibroblasts in the normal pancreas. WT1 expression also identifies a population of CAFs in both human and mouse pancreatic cancers. In this study, we investigated the contribution of WT1+ mesenchymal cells to CAF populations and evaluated the functional role of WT1+ stromal cells in pancreatic cancer. Lineage tracing revealed that WT1+ cells expand in pancreatic cancer, giving rise to a populati","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T11:49:16.403Z","creation":"2026-07-06T03:08:35.01Z"},"accession":"S-EPMC12809115","cross_references":{"pubmed":["41032745"],"doi":["10.1158/0008-5472.CAN-25-1014"]}}