{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iftehimul M"],"funding":["NINDS NIH HHS","National Institutes of Health","North Carolina A&amp;amp;T State University","NIGMS NIH HHS"],"pagination":["169-178"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809272"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31"],"pubmed_abstract":["<h4>Background</h4>The triple-negative breast cancer (TNBC) microenvironment undergoes progressive reprogramming, transitioning from an early immune-active state to a late immune-suppressed state. While tumor cell plasticity has been extensively studied, the temporal molecular remodeling of T cells <i>in vivo</i> remains poorly defined.<h4>Results</h4>Transcriptional analysis of T cells within 4T1 TNBC tumors, harvested at one-, three-, and six-weeks post-tumor implantation in the mammary fat pads of BALB/c mice, revealed a decline in transcriptomic signatures associated with T cells from 194 at one week to 156 at six weeks, with a significant late-stage loss or reduction of transcripts related to T cell receptors (TCR), natural killer T, and gamma delta T cells. Furthermore, changes in va"],"journal":["Computational and structural biotechnology journal"],"pubmed_title":["Temporal molecular remodeling of T cells informs their possible adaptation in 4T1 tumors."],"pmcid":["PMC12809272"],"funding_grant_id":["R35 GM153737","R16 NS147983"],"pubmed_authors":["Kaufman HL","Muganda PM","Saha D","Newman RH","Rorie CJ","Graves JL","Jones RB","Iftehimul M","Harrison SH","Holloman BL","Thomas MD","Hossain MT"],"additional_accession":[]},"is_claimable":false,"name":"Temporal molecular remodeling of T cells informs their possible adaptation in 4T1 tumors.","description":"<h4>Background</h4>The triple-negative breast cancer (TNBC) microenvironment undergoes progressive reprogramming, transitioning from an early immune-active state to a late immune-suppressed state. While tumor cell plasticity has been extensively studied, the temporal molecular remodeling of T cells <i>in vivo</i> remains poorly defined.<h4>Results</h4>Transcriptional analysis of T cells within 4T1 TNBC tumors, harvested at one-, three-, and six-weeks post-tumor implantation in the mammary fat pads of BALB/c mice, revealed a decline in transcriptomic signatures associated with T cells from 194 at one week to 156 at six weeks, with a significant late-stage loss or reduction of transcripts related to T cell receptors (TCR), natural killer T, and gamma delta T cells. Furthermore, changes in va","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-07-15T06:35:05.077Z","creation":"2026-06-30T03:21:44.384Z"},"accession":"S-EPMC12809272","cross_references":{"pubmed":["41550137"],"doi":["10.1016/j.csbj.2025.12.022"]}}