{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Barton K"],"pubmed_abstract":["The Wagner-Jauregg reaction produces up to four new carbon-carbon bonds and eight new stereocenters, but limitations, such as high requisite temperatures, a restricted substrate scope, and significant undesired polymer formation, have resulted in this reaction receiving minimal attention. While generally considered a subtype of the Diels-Alder reaction, in which a styrenyl diene is employed in a tandem double-Diels-Alder reaction, a second, structurally distinct, stereochemically complex product can also be produced by the Wagner-Jauregg reaction, resulting from a Diels-Alder-ene cascade. Very few attempts to improve reaction conditions, expand substrate scope, or optimize product selectivity have been published. Through reaction optimization, supplemented by density functional theory calc"],"journal":["ACS omega"],"pagination":["1360-1368"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809351"],"repository":["biostudies-literature"],"pubmed_title":["Enhanced Reactivity for the Wagner-Jauregg Reaction Under Aqueous Conditions."],"pmcid":["PMC12809351"],"pubmed_authors":["Tartakoff SS","Barton K","Tartakoff SA","Stasio J","Hill AD","Smith C","Rothe E","Dickhens L"],"additional_accession":[]},"is_claimable":false,"name":"Enhanced Reactivity for the Wagner-Jauregg Reaction Under Aqueous Conditions.","description":"The Wagner-Jauregg reaction produces up to four new carbon-carbon bonds and eight new stereocenters, but limitations, such as high requisite temperatures, a restricted substrate scope, and significant undesired polymer formation, have resulted in this reaction receiving minimal attention. While generally considered a subtype of the Diels-Alder reaction, in which a styrenyl diene is employed in a tandem double-Diels-Alder reaction, a second, structurally distinct, stereochemically complex product can also be produced by the Wagner-Jauregg reaction, resulting from a Diels-Alder-ene cascade. Very few attempts to improve reaction conditions, expand substrate scope, or optimize product selectivity have been published. Through reaction optimization, supplemented by density functional theory calc","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-12T04:51:56.772Z","creation":"2026-06-12T03:08:20.536Z"},"accession":"S-EPMC12809351","cross_references":{"pubmed":["41552472"],"doi":["10.1021/acsomega.5c07465"]}}