biostudies-literatureUnknown11(1)Silva Neto LDConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São PauloLayered Double Hydroxides (LDH) are an important class of inorganic nanomaterials characterized by variable composition, high porosity, significant surface area, and notable ion-exchange capacity. Although coprecipitation is the most widely used synthesis method, the subsequent drying step is often critically overlooked, as it directly affects particle agglomeration and degradation of the porous colloidal structure. This study evaluated the influence of the drying process on MgAl-CO₃/LDH synthesis by determining the effective diffusivity (<i>D</i> _eff) and activation energy (<i>E</i> _a). LDHs were synthesized via coprecipitation (Mg/Al ratio = 2:1). Drying kinetics were investigated at 75, 90, and 105 °C, both without and with forced-air convection (1.0 ± 0ACS omega1867-1873https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809506biostudies-literatureMathematical Modeling of LDH Nanoparticle Drying: Evaluating Effective Diffusivity and the Role of the Mass Biot Number.PMC12809506Silva Neto LDLogetto Caetite Gomes TMeili LJunqueira Brandao RTeixeira Freire JfalseMathematical Modeling of LDH Nanoparticle Drying: Evaluating Effective Diffusivity and the Role of the Mass Biot Number.Layered Double Hydroxides (LDH) are an important class of inorganic nanomaterials characterized by variable composition, high porosity, significant surface area, and notable ion-exchange capacity. Although coprecipitation is the most widely used synthesis method, the subsequent drying step is often critically overlooked, as it directly affects particle agglomeration and degradation of the porous colloidal structure. This study evaluated the influence of the drying process on MgAl-CO₃/LDH synthesis by determining the effective diffusivity (<i>D</i> _eff) and activation energy (<i>E</i> _a). LDHs were synthesized via coprecipitation (Mg/Al ratio = 2:1). Drying kinetics were investigated at 75, 90, and 105 °C, both without and with forced-air convection (1.0 ± 02026-01-01T00:00:00Z2026 Jan2026-06-06T14:03:00.281Z2026-05-31T03:10:20.282ZS-EPMC128095064155258410.1021/acsomega.5c10016