{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Durant A"],"funding":["H. Lundbeck A/S","Lumosity","NIA NIH HHS","the National Institute on Aging","Alzheimer's Drug Discovery Foundation","Cogstate","National Institutes of Health","Alzheimer&apos;s Association","National Institute on Aging","Eli Lilly and Company","Laboratory for Neuro Imaging","the Wisconsin Registry for Alzheimer's Prevention","Novartis Pharmaceuticals Corporation","EuroImmun","Northern California Institute for Research and Education","NINDS NIH HHS","Meso Scale Diagnostics, LLC.","Araclon Biotech","Servier","Alzheimer's Association","NIH HHS","Bristol-Myers Squibb","F. Hoffmann-La Roche Ltd.","Alzheimer's Therapeutic Research Institute","Janssen Alzheimer Immunotherapy Research & Development, LLC.","Elan Pharmaceuticals, Inc.","Bristol-Myers Squibb Company","the Alzheimer's Disease Neuroimaging Initiative","the National Institute of Biomedical Imaging and Bioengineering","Genentech, Inc.","Genentech","F. Hoffmann-La Roche","Pfizer Inc.","Illinois Department of Public Health","IXICO Ltd.","GE Healthcare","Canadian Institutes of Health Research","CereSpir, Inc.","Fujirebio","Transition Therapeutics","Takeda Pharmaceutical Company","Alzheimer&apos;s Drug Discovery Foundation","BioClinica","Johnson & Johnson Pharmaceutical Research & Development LLC","Pfizer","following: AbbVie","University of Southern California","Neurotrack Technologies","BioClinica, Inc.","CIHR","Piramal Imaging","NeuroRx Research","The ADSP Phenotype Harmonization Consortium","Fujirebio US","Biogen","Lundbeck"],"pagination":["e71024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809718"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Introduction</h4>\"SuperAgers\" are oldest-old adults (ages 80+) whose memory performance more closely resembles middle-aged adults. The present study examined apolipoprotein E (APOE) allele frequency in non-Hispanic Black (NHB) and non-Hispanic White (NHW) SuperAgers compared to controls and Alzheimer's disease dementia cases.<h4>Methods</h4>In 18,080 participants from eight cohorts, harmonized clinical diagnostics and memory, executive function, and language domain scores were used to identify SuperAgers, cases, and controls across age-defined bins.<h4>Results</h4>NHW SuperAgers had significantly lower frequency of APOE-ε4 alleles and higher frequency of APOE-ε2 alleles compared to all cases and controls, including oldest-old controls. Similar patterns were found in a small yet substan"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers."],"pmcid":["PMC12809718"],"funding_grant_id":["R01 AG054047","R01 AG059716","K24 AG046373","R01 AG056405","R01 AG15819","U19 AG066567","UH2 NS100599","R01 AG037639","K01 AG073584","R01 AG0271761","U01 AG068057","W81XWH-12-2-0012","P30 AG10161","P30 AG072975","R01 AG064233","U24 AG074855","R01 AG022018","R01 AG067482","U24 AG072122","R01 AG021155","U01 AG024904","R01 AG017917","UH3 NS100599"],"pubmed_authors":["Mez J","Barnes LL","Scollard P","Jefferson AL","Martin ER","Naj AC","Kukull WA","Haines JL","Cuccaro ML","Pericak-Vance MA","Gaynor LS","Johnson SC","Klinedinst BS","Farrer LA","Durant A","Alzheimer's Disease Neuroimaging Initiative (ADNI)*Alzheimer's Disease Genetics Consortium (ADGC)The Alzheimer's Disease Sequencing Project (ADSP)","Vardarajan BN","Saykin AJ","Albert MS","Dumitrescu L","Mayeux R","Hassenstab J","Wang LS","Crane PK","Hohman TJ","Kunkle BW","Cruchaga C","Engelman CD","Archer DB","Bush WS","Bennett DA","Schneider JA","Choi SE","Gifford KA","Mukherjee S","Trittschuh EH","Thompson PM","Keene CD","Lee ML"],"additional_accession":[]},"is_claimable":false,"name":"Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.","description":"<h4>Introduction</h4>\"SuperAgers\" are oldest-old adults (ages 80+) whose memory performance more closely resembles middle-aged adults. The present study examined apolipoprotein E (APOE) allele frequency in non-Hispanic Black (NHB) and non-Hispanic White (NHW) SuperAgers compared to controls and Alzheimer's disease dementia cases.<h4>Methods</h4>In 18,080 participants from eight cohorts, harmonized clinical diagnostics and memory, executive function, and language domain scores were used to identify SuperAgers, cases, and controls across age-defined bins.<h4>Results</h4>NHW SuperAgers had significantly lower frequency of APOE-ε4 alleles and higher frequency of APOE-ε2 alleles compared to all cases and controls, including oldest-old controls. Similar patterns were found in a small yet substan","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T14:40:22.419Z","creation":"2026-05-31T03:10:16.346Z"},"accession":"S-EPMC12809718","cross_references":{"pubmed":["41542929"],"doi":["10.1002/alz.71024"]}}