biostudies-literatureDurant AH. Lundbeck A/SLumosityNIA NIH HHSthe National Institute on AgingAlzheimer's Drug Discovery FoundationCogstateNational Institutes of HealthAlzheimer&apos;s AssociationNational Institute on AgingEli Lilly and CompanyLaboratory for Neuro Imagingthe Wisconsin Registry for Alzheimer's PreventionNovartis Pharmaceuticals CorporationEuroImmunNorthern California Institute for Research and EducationNINDS NIH HHSMeso Scale Diagnostics, LLC.Araclon BiotechServierAlzheimer's AssociationNIH HHSBristol-Myers SquibbF. Hoffmann-La Roche Ltd.Alzheimer's Therapeutic Research InstituteJanssen Alzheimer Immunotherapy Research & Development, LLC.Elan Pharmaceuticals, Inc.Bristol-Myers Squibb Companythe Alzheimer's Disease Neuroimaging Initiativethe National Institute of Biomedical Imaging and BioengineeringGenentech, Inc.GenentechF. Hoffmann-La RochePfizer Inc.Illinois Department of Public HealthIXICO Ltd.GE HealthcareCanadian Institutes of Health ResearchCereSpir, Inc.FujirebioTransition TherapeuticsTakeda Pharmaceutical CompanyAlzheimer&apos;s Drug Discovery FoundationBioClinicaJohnson & Johnson Pharmaceutical Research & Development LLCPfizerfollowing: AbbVieUniversity of Southern CaliforniaNeurotrack TechnologiesBioClinica, Inc.CIHRPiramal ImagingNeuroRx ResearchThe ADSP Phenotype Harmonization ConsortiumFujirebio USBiogenLundbecke71024https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809718biostudies-literatureUnknown22(1)<h4>Introduction</h4>"SuperAgers" are oldest-old adults (ages 80+) whose memory performance more closely resembles middle-aged adults. The present study examined apolipoprotein E (APOE) allele frequency in non-Hispanic Black (NHB) and non-Hispanic White (NHW) SuperAgers compared to controls and Alzheimer's disease dementia cases.<h4>Methods</h4>In 18,080 participants from eight cohorts, harmonized clinical diagnostics and memory, executive function, and language domain scores were used to identify SuperAgers, cases, and controls across age-defined bins.<h4>Results</h4>NHW SuperAgers had significantly lower frequency of APOE-ε4 alleles and higher frequency of APOE-ε2 alleles compared to all cases and controls, including oldest-old controls. Similar patterns were found in a small yet substanAlzheimer's & dementia : the journal of the Alzheimer's AssociationEvaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.PMC12809718R01 AG054047R01 AG059716K24 AG046373R01 AG056405R01 AG15819U19 AG066567UH2 NS100599R01 AG037639K01 AG073584R01 AG0271761U01 AG068057W81XWH-12-2-0012P30 AG10161P30 AG072975R01 AG064233U24 AG074855R01 AG022018R01 AG067482U24 AG072122R01 AG021155U01 AG024904R01 AG017917UH3 NS100599Mez JBarnes LLScollard PJefferson ALMartin ERNaj ACKukull WAHaines JLCuccaro MLPericak-Vance MAGaynor LSJohnson SCKlinedinst BSFarrer LADurant AAlzheimer's Disease Neuroimaging Initiative (ADNI)*Alzheimer's Disease Genetics Consortium (ADGC)The Alzheimer's Disease Sequencing Project (ADSP)Vardarajan BNSaykin AJAlbert MSDumitrescu LMayeux RHassenstab JWang LSCrane PKHohman TJKunkle BWCruchaga CEngelman CDArcher DBBush WSBennett DASchneider JAChoi SEGifford KAMukherjee STrittschuh EHThompson PMKeene CDLee MLfalseEvaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.<h4>Introduction</h4>"SuperAgers" are oldest-old adults (ages 80+) whose memory performance more closely resembles middle-aged adults. The present study examined apolipoprotein E (APOE) allele frequency in non-Hispanic Black (NHB) and non-Hispanic White (NHW) SuperAgers compared to controls and Alzheimer's disease dementia cases.<h4>Methods</h4>In 18,080 participants from eight cohorts, harmonized clinical diagnostics and memory, executive function, and language domain scores were used to identify SuperAgers, cases, and controls across age-defined bins.<h4>Results</h4>NHW SuperAgers had significantly lower frequency of APOE-ε4 alleles and higher frequency of APOE-ε2 alleles compared to all cases and controls, including oldest-old controls. Similar patterns were found in a small yet substan2026-01-01T00:00:00Z2026 Jan2026-06-06T14:40:22.419Z2026-05-31T03:10:16.346ZS-EPMC128097184154292910.1002/alz.71024