{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Le TT"],"pubmed_abstract":["<i>Morus alba</i> L. root bark (MAR, \"Sang-Bai-Pi\" in traditional Chinese medicine) has been traditionally used for the treatment of inflammatory disorders. Phytochemical investigation of MAR yielded 11 new flavanones and one new chalcone (<b>1</b>-<b>12</b>, morutamins A-L), along with 27 known compounds (<b>13</b>-<b>39</b>). Their structures and absolute configurations were elucidated by combining HRESIMS and NMR analyses with DP4 and DP4+ probability calculations and ECD data. Among these, morutamin L (<b>12</b>) exhibited potent anti-inflammatory and immunomodulatory activities by inhibiting epidermal growth factor receptor and toll-like receptor agonist-induced NF-κB/AP-1 activation, which were explored through network pharmacology, molecular docking, and experimental verification. S"],"journal":["ACS omega"],"pagination":["2246-2262"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809818"],"repository":["biostudies-literature"],"pubmed_title":["Morutamins A-L from &lt;i&gt;Morus alba&lt;/i&gt; L. Root Bark with Inhibitory Effects on Epidermal Growth Factor Receptor and Toll-Like Receptor-Mediated NF-κB/AP‑1 Activation."],"pmcid":["PMC12809818"],"pubmed_authors":["Jung SH","Lee WB","Jung Y","Tran SH","Le TT","Cha JW","Kang TK","Bang M","Kang K"],"additional_accession":[]},"is_claimable":false,"name":"Morutamins A-L from &lt;i&gt;Morus alba&lt;/i&gt; L. Root Bark with Inhibitory Effects on Epidermal Growth Factor Receptor and Toll-Like Receptor-Mediated NF-κB/AP‑1 Activation.","description":"<i>Morus alba</i> L. root bark (MAR, \"Sang-Bai-Pi\" in traditional Chinese medicine) has been traditionally used for the treatment of inflammatory disorders. Phytochemical investigation of MAR yielded 11 new flavanones and one new chalcone (<b>1</b>-<b>12</b>, morutamins A-L), along with 27 known compounds (<b>13</b>-<b>39</b>). Their structures and absolute configurations were elucidated by combining HRESIMS and NMR analyses with DP4 and DP4+ probability calculations and ECD data. Among these, morutamin L (<b>12</b>) exhibited potent anti-inflammatory and immunomodulatory activities by inhibiting epidermal growth factor receptor and toll-like receptor agonist-induced NF-κB/AP-1 activation, which were explored through network pharmacology, molecular docking, and experimental verification. S","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-10T05:27:27.046Z","creation":"2026-06-10T03:07:30.334Z"},"accession":"S-EPMC12809818","cross_references":{"pubmed":["41552606"],"doi":["10.1021/acsomega.5c11810"]}}