biostudies-literatureUnknown11(1)Shah RVGroundwater isotopic screening has gained increased attention for determining the α activity ratio of ²³⁴U/²³⁸U. This requires efficient uranium preconcentration from aquifer samples and precise measurement of the minor abundant isotope ratio of ²³⁴U/²³⁸U (approximately 55 ppm). Using polydopamine-coated Fe₃O₄ magnetic nanoparticles (PDA@Fe₃O₄-NPs) to extract uranium from aquifer samples reduces analysis time by over 80% compared to conventional preconcentration methods. Thermal Ionization mass spectrometry (TIMS) with carefully selected detector combinations and a novel methodology was employed to measure the ²³⁴U/²³⁸U isotope ratio. The methodology involves sequentially collectinACS omega361-370https://www.ebi.ac.uk/biostudies/studies/S-EPMC12809863biostudies-literatureNanoparticle-Assisted Uranium Extraction and Precise Isotopic Fingerprinting in Groundwater by TIMS.PMC12809863Jaison PGBhushan KSGoswami PSanyal KShah RVfalseNanoparticle-Assisted Uranium Extraction and Precise Isotopic Fingerprinting in Groundwater by TIMS.Groundwater isotopic screening has gained increased attention for determining the α activity ratio of ²³⁴U/²³⁸U. This requires efficient uranium preconcentration from aquifer samples and precise measurement of the minor abundant isotope ratio of ²³⁴U/²³⁸U (approximately 55 ppm). Using polydopamine-coated Fe₃O₄ magnetic nanoparticles (PDA@Fe₃O₄-NPs) to extract uranium from aquifer samples reduces analysis time by over 80% compared to conventional preconcentration methods. Thermal Ionization mass spectrometry (TIMS) with carefully selected detector combinations and a novel methodology was employed to measure the ²³⁴U/²³⁸U isotope ratio. The methodology involves sequentially collectin2026-01-01T00:00:00Z2026 Jan2026-06-06T13:52:07.018Z2026-05-31T03:09:51.625ZS-EPMC128098634155255110.1021/acsomega.5c02946